Stepped wedgeIn stepped wedge (SW) designs, differing cluster-level characteristics or individual-level covariate distributions that differ by cluster can lead to imbalance by treatment arm and potential confou
In this section we examine a number of issues related to the design and analysis of stepped wedge CRTs. Discussion Using theoretical calculations and simulation we have investigated statistical characteristics of the stepped wedge design for cluster randomized trials. In particular, we have outlined a...
stepped wedgeStandard sample size calculation formulas for stepped wedge cluster randomized trials (SW〤RTs) assume that cluster sizes are equal. When cluster sizes vary substantially, ignoring this variation may lead to an under﹑owered study. We investigate the relative efficiency of a SW〤RT ...
The use of Stepped Wedge cluster randomized trials: Systematic Review Dr Celia Taylor The University of Birmingham On behalf of my co-authors: Noreen Mdege, Mei-See Man and David Torgerson (University of York) Today’s presentation What is a stepped wedge design? What are the advantages and...
et al. Telemedicine-based antibiotic stewardship program in pediatrics: study protocol of a stepped wedge cluster randomized trial—the TeleKasper study. Trials 25, 678 (2024). https://doi.org/10.1186/s13063-024-08493-z Download citation Received12 April 2024 Accepted20 September 2024 Published14...
stepped‐wedgeThe ability to accurately estimate the sample size required by a stepped‐wedge (SW) cluster randomized trial (CRT) routinely depends upon the specification of several nuisance parameters. If these parameters are misspecified, the trial could be overpowered, leading to increased cost, ...
Design and analysis of stepped wedge cluster randomized trials. Contemporary Clin Trials. 2007;28(2):182–91. https://doi.org/10.1016/j.cct.2006.05.007. Article Google Scholar Yousafzai AK, Rasheed MA, Rizvi A, Armstrong R, Bhutta ZA. Effect of integrated responsive stimulation and nutrition...
Systematic review of stepped wedge cluster randomized trials shows that design is particularly used to evaluate interventions during routine implementation. J Clin Epidemiol. 2011;64(9):936–48. Article PubMed Google Scholar Hussey MA, Hughes JP. Design and analysis of stepped wedge cluster ...
Stepped-wedge cluster rando-mised controlled trials: a generic framework including parallel and multiple-level designs[J]. Statistics in Medicine, 2015, 34(2): 181 – 196. DOI: 10.1002/sim.6325 [5] Hussey MA, Hughes JP. Design and analysis of stepped wedge cluster randomized trials[J]. ...
Brown CA, Lilford RJ. The stepped wedge trial design: a systematic review. BMC Med Res Methodol. 2006;6:54. Grayling MJ, Wason JM, Mander AP. Stepped wedge cluster randomized controlled trial designs: a review of reporting quality and design features. Trials. 2017;18(1):33. ...