This system (like all others) undergoes physiological regeneration due to many types of stem cells found both in the respiratory tract itself and in the alveoli. The stem cell hierarchy is very extensive due to their variety in the lungs and is still not completely understood.The best described...
Epithelial cells line and protect the airways and produce a protein known as Sonic hedgehog. Via this protein, epithelial cells signal the stem-cell-likemesenchymal cells, which make up the scaffolding of the lungs, to make FOXF1, a repressor that keeps the stem cells in check. "We are jus...
The research began with an insight: Certainstem cellsthat normally reside in the lungs are highly similar to those in the bone marrow. In each organ, the stem cells, rather than being distributed throughout the tissue, are concentrated in special compartments that contain all the provisions that...
Stem/Progenitor Cell Populations Resident in the Lung and the Role of Stromal Support in Their Maintenance and Differentiation Chapter © 2019 Lung Stem Cells and Their Use for Patient Care: Are We There Yet? Chapter © 2016 Stem Cells in Lungs Chapter © 2019 Abbreviations...
In the new study, Snoeck's team discovered new chemicals that complete the conversion of stem cells into the epithelial cells that coat the surface of the lungs. In fact, the researchers found evidence suggesting the cells could develop into six types of lung and airway epithelial cells, accord...
阅读理解Stem cells(干细胞) have the great potential to develop into many different cell types in the body during early life and growth. In addition, in many tissues they serve as a sort of inner repair system, dividing essentially without limit to add other cells as long as the person or...
cells in aged lungs exhibit reduced AMPK-PFKFB2 signaling and ATP production, resulting in impaired alveolar regeneration. Activating AMPK-PFKFB2 signaling in aged AT2 cells can rescue defective alveolar regeneration in aged ...
Epithelial Sodium Channels in Pulmonary Epithelial Progenitor and Stem Cells Regeneration of the epithelium of mammalian lungs is essential for restoring normal function following injury, and various cells and mechanisms contribute ... L Yang,BJ Jiang,RZ Zhao,... - 《International Journal of Biological...
AREG is significantly upregulated in intermediate AT2 cells of IPF lungs AREG 在 IPF 肺的中间 AT2 细胞中显着上调 背景:上面主要是将的在Cdc42 AT2 null肺中上调,这儿想看看是不是在中间AT2中上调 实验方法:通过免疫荧光分析,研究者在IPF患者和健康供体的肺组织中检测AREG的表达。
Human lungs are constantly exposed to inhaled chemicals that have the potential to damage cellular DNA. Lung stem cells must therefore have the ability to repair DNA damage to survive and achieve tissue homeostasis. Lung airways are composed of different types of cells, including basal cells, ...