Stem Cells and Lung CancerAdam Yagui-Beltra´ n, Biao He, and David M. JablonsAbstract Lung cancer with its more than 1 million deaths per year is the leadingcause of cancer mortality for both men and women worldwide. Despite recentadvances in current treatment modalities, overall survival ...
There have been recent advances in isolation and characterization of the putative cells of origin associated with non-small cell lung cancer and small cell lung cancer. Key biochemical pathways involved in stem cell maintenance have demonstrated potential therapeutic relevance. Basel cells of the ...
shared insight on his research in stem cells and why discovering which cells have the potential to form lung cancer is significant to the treatment paradigm.My focus was on the very early stages of lung cancer development by asking, which cells are capable of forming cancer?
2.6 Lung stem cells and lung cancer stem cells The lung is a complex organ made up of regionally and functionally distinct cell phenotypes. A diverse class of lung stem cells drives the development and turnover of these populations. The epithelium of the adult airways consists of three distinct...
Wnt Signaling in Stem Cells and Lung Cancer The Wnt signal transduction pathway plays important roles during embryo development, regulating cell proliferation and survival of immature cells. However,... B He,D M Jablons - 《Ernst Schering Research Foundation Workshop》 被引量: 116发表: 2006年 ...
distinct biological characterization of the cd44 and cd90 phenotypes of cancer stem cells in gastric cancer cell lines (2019).[10.1007s11010-019-03 热度: Patient-Derived Xenografts of Non Small Cell Lung Cancer Resurgence of an Old Model for Investigation of Modern Concepts of Tailored Therapy...
Cancer stem cell (CSC) theory states that tumors are organized in a similar hierarchical manner as normal tissues, with a sub-population of tumorigenic stem-like cells that generate the more differentiated nontumorigenic tumor cells. CSCs are chemoresist
Lung cancer is the most lethal form of cancer in the world and despite significant therapeutic improvements that have been made, its survival rate still re
Cancer stem cells are rare immortal cells within a tumour that can both self-renew by dividing and give rise to many cell types that constitute the tumour, and can therefore form tumours. Such cells have been found in various types of human tumours and might be attractive targets for cancer...
The cancer stem cell (CSC) model is based on a myriad of experimental and clinical observations suggesting that the malignant phenotype is sustained by a subset of cells characterized by the capacity for self-renewal, differentiation and innate resistance to chemotherapy and radiation. CSC may be ...