This system (like all others) undergoes physiological regeneration due to many types of stem cells found both in the respiratory tract itself and in the alveoli. The stem cell hierarchy is very extensive due to their variety in the lungs and is still not completely understood.The best described...
Characterizing the stem cells responsible for lung repair and regeneration is important for the treatment of pulmonary diseases. Recently, a unique cell population located at the bronchioalveolar-duct junctions has been proposed to comprise endogenous stem cells for lung regeneration. However, the role...
[Inside Life Science: Once Upon a Stem Cell] In 2011, Snoeck and his colleagues found a set of chemical signals capable of transforming two types of stem cells — human embryonic stem cells, which are taken from human embryos, and induced pluripotent stem (iPS) cells, which are adult skin...
Fig. 1. Cell population diversity and location in human lungs and corresponding on-chip models. For each on-chip model, cell origin is indicated (L = human cell line; P = human-derived primary cells). The distal, respiratory part of the lungs contains an average of 450 million ...
stem cell compartments with a method they had developed, and then the new stem cells were injected into mouse models of lung damage. The embryonic lung stem cells managed to find their way through the blood to the lungs and settle into the proper compartment. By six weeks, these cells were...
So, can stem cells cure lung fibrosis? Or at least, can stem cell therapy help pulmonary fibrosis in some way? Let’s take a look at what’s currently known. What Is Pulmonary Fibrosis, and How Does It Affect the Lungs? Pulmonary fibrosis is a serious condition that affects the lungs,...
Extended Data Figure 9 Stem cell transplantation reduces interstitial densities in DASCp63/Krt5-ablated lungs. a, Histological sections through entire lobe of Krt6–DTR mice with (left) and without (right) diphtheria toxin treatment forty days post-influenza infection. b, Histogram of morphometric ...
这篇文献的标题是 "Sustained amphiregulin expression in intermediate alveolar stem cells drives progressive fibrosis",作者包括 Rui Zhao, Zheng Wang, Guowu Wang 等,发表在《Cell Stem Cell》杂志上,于2024年9月5日发表。 摘要 - 研究背景:特发性肺纤维化(IPF)是一种致命的纤维化疾病,目前治疗效果有限。
which is essential to support the intracellular energy expenditure that is required for cytoskeletal remodeling during AT2 cell differentiation. AT2 cells in aged lungs exhibit reduced AMPK-PFKFB2 signaling and ATP production, ...
The lung is a relatively quiescent tissue comprised of infrequently proliferating epithelial, endothelial, and interstitial cell populations. No classical stem cell hierarchy has yet been described for the maintenance of this essential tissue; however, after injury, a number of lung cell types are able...