Here we show that druggable biological targets and small-molecule regulators of intestinal stem cell differentiation can be identified via multiplexed phenotypic screening using thousands of miniaturized organoid models of intestinal stem cell differentiation into Paneth cells, and validated via longitudinal ...
In addition, MSCs can modulate T-cell functions by skewing Th-1 T-cell responses toward Th-2 T-cell responses, but also by the induction of CD4+CD25+Foxp3+ T cells (T regs) and the inhibition of naive CD4+ T differentiation into Th-17 cells. Moreover, MSCs impair the differentiation...
To better understand the role of DDR1 in differentiation, we performed scRNA-seq using Seq-Well14to generate a comparative cellular atlas at single-cell resolution on human breast tissues grown for 14 days in 3D hydrogels under three different conditions: 1) vehicle-treated control, 2) DDR1-in...
Myelodysplastic neoplasms (MDS) are a group of heterogeneous malignant hematopoietic stem cell (HSC) diseases which are characterized by disordered growth and differentiation of hematopoietic stem cells and a high risk of transformation to acute myeloid leukemia (AML) [1]. Although multiple new drugs ...
The mechanism behind the therapeutic effect of MSCs was initiallybelieved to be mainly through engraftment in host tissue and replacement of depleted or faulty cell types via differentiation. However, recent studies have indicated that MSCs may also exhibit additional beneficial effects through paracrine ...
Estrogen -receptor-dependent regulation of neural stem cell proliferation and differentiation. Mol Cell Neurosci, 2002 Estrogen has profound effects on function and plasticity of the nervous system. Receptors for estrogen (ERs) are expressed by neurons in several areas of t... K Brännvall,L ...
The present invention provides a composition for promoting and protecting neural stem cell differentiation, and a method of inducing nerve regeneration using the composition. The present invention relates to a method of inducing nerve regeneration, comprising administering a MEK1 / 2 inhibitor to a ...
Author Correction: Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells The error has been corrected in the HTML and PDF versions of the paper.doi:10.1038/s41556-019-0316-3Nair, Gopika G.Liu, Jennifer S.Russ, Holger A.Tran, StellaSaxton...
Within a given pathway topology, three measurable quantities are closely related: the rates of cell differentiation and proliferation at each node define the size of the cell population constituting this node (Supplementary Fig. 4a). The in vivo values of differentiation rates, proliferation rates, ...
PDAC is generated by PDAC stem cell differentiation. Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 24,99 €/ 30 days cancel any time Learn more Buy this article ...