Yulian et al. found that simvastatin combined with FAC (Fluorouracil, adriamycin and cyclophosphamide) improved the response to neoadjuvant chemotherapy in patients with advanced local breast cancer [49]. Cantini et al. found that high-intensity statins enhanced the clinical activity...
appropriate high-intensity statin use remained low.18 Approximately two thirds of adults taking statins for secondary prevention do not take the high-intensity dose advised by major guidelines.19–21 In addition, primary nonadherence, that is, never filling a newly prescribed medication, occurs in a...
FIG. 4 contains graphs showing that atorvastatin increases the phagocytic function of ARPE-19 cells. (A) Percent of phagocytic cells, represented by beads-positive cells or Y axis, and the phagocytic index, represented by fluorescence intensity or X axis, as determined by flow cytometry of ARPE-...
Flow chart of the number of studies identified and included into the meta-analysis. 3. Results 3.1. Effects of Statin Intensity on Circulating Concentrations of ox-LDL Meta-analysis of data from 4 trials including 381 patients suggested a significant decrease in circulating concentrations of ox-LDL...
This invention can kill these antibiotic-resistant bacteria. One problem is that as the bacteria are killed they release endotoxins, and/or other toxic biochemicals, into the cytoplasm, causing further disease symptoms, sometimes of even higher intensity than during the actual activity of the Th1 di...
High-intensity regimens are defined as doses of statins that reduce LDL-C by 50% on average, and medium-intensity therapy is defined as doses that reduce LDL-C by 30–50% [59]. However, the degree of statin-induced LDL-C reduction varies from person to person and is affected by ...
Nissen, S.E.; Nicholls, S.J.; Sipahi, I.; Libby, P.; Raichlen, J.S.; Ballantyne, C.M.; Davignon, J.; Erbel, R.; Fruchart, J.C.; Tardif, J.-C. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: The ASTEROID trial. JAMA 2006, 295, 1556...
High-intensity regimens are defined as doses of statins that reduce LDL-C by 50% on average, and medium-intensity therapy is defined as doses that reduce LDL-C by 30–50% [59]. However, the degree of statin-induced LDL-C reduction varies from person to person and is affected by ...
Thus, the main objective of the present study was to examine the chemoprotective effect of statins on CRC as a whole group and by active principle, which in turn would allow us to test whether such is a class effect and whether it is dependent on their lipophilicity and intensity. As a ...
PCSK9 inhibitor can be considered in those who are unable to achieve a >50% reduction in LDL-C or whose LDL-C remains ≥55 mg/dL (or whose non–HDL-C remains ≥85 mg/dL) despite maximally tolerated statin therapy, or who are unable to tolerate even low-intensity statin therapy or al...