Accordingly, we designed the ASTEROID trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) to examine the effects of high-intensity statin therapy on IVUS-derived measures of coronary disease progression. Rosuvastatin is the most recently ...
intensity statin and compare admission statin to the discharge statin prescriptionThe findings of this review will be used to assist in modifying protocols that promote appropriate statin dosing for secondary prevention in high-risk coronary artery disease patients.Methods:Conduct a retrospective chart ...
1A), the calyx region shows only weak immunoreactivity but signal intensity increases towards the distal parts of the lobes, where strong immunolabeling can be detected. In R. maderae, orcokinin-immunoreactive processes from extrinsic neurons innervate the basal parts of the calyces, the peduncle ...
Finally, statin orders were preselected on the basis of the patient’s risk (moderate or high intensity), and a full chart with dosing options was made available in case a clinician wanted to select another statin. Design details like these are often critical to intervention success.23 Future ...
All the patients were candidates for high-intensity statin therapy. The participants were either predisposed to or already had atherosclerotic cardiovascular disease (ASCVD). Approximately two-thirds (62%) of the subjects were on low-dose aspirin as a prophylactic therapy for CVD events. None of ...
The ASTEROID trial even showed regression of coronary atherosclerosis with very high-intensity statin therapy (Nissen et al., 2006). Similarly, Yu et al. showed that intensive but not regular-dose atorvastatin therapy resulted in regression of carotid atherosclerotic disease (Yu et al., 2007) and...
Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, Davignon J, Erbel R, Fruchart JC, Tardif JC, etal: Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA. 2006, 295 (13): 1556-1565. 10.1001/jama.295.13....
An H-score was calculated based on the extent and intensity of cytoplasmic or nuclear staining where appropriate (H-score=3 × % of strongly staining cytoplasm+2 × % of moderately staining cytoplasm+1 × % of weakly staining cytoplasm, giving a range of 0–300) (McCarty et al, 1986). ...
High-intensity statin therapy is associated with a higher rate of transaminase elevations, but no hepatic failure, a very small risk of myopathy, and an increased risk of developing diabetes. However, the small increase in the risk of developing diabetes is much smaller than the marked lowering ...
intensity statin prescription for patients with ASCVD or DM by medical resident trainees in our single-center primary care clinic. A total of 77% of cardiovascular disease patients were found to be on an appropriate statin dose at baseline. On the other hand, the proportion of patients with DM...