Accordingly, we designed the ASTEROID trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) to examine the effects of high-intensity statin therapy on IVUS-derived measures of coronary disease progression. Rosuvastatin is the most recently ...
Influence of Statin Intensity on Prognostic Impacts in Patients with Ischemic Heart Failure-A Report From the CHART-2 Study-doi:10.1016/j.cardfail.2016.07.108Oikawa, TakuyaSakata, YasuhikoYamauchi, TakeshiTsuji, KanakoOnose, TakeoKasahara, Shintaro...
CYP3A4*1B and CYP3A5*3 SNPs significantly impact the response of Egyptian candidates to high-intensity statin therapy to atorvastatin Mohammed G. Maslub, Nur Aizati Athirah Daud, Mahasen A. Radwan, Abubakar Sha’aban & Arafa G. Ibrahim European Journal of Medical Research volume 29,...
Finally, statin orders were preselected on the basis of the patient’s risk (moderate or high intensity), and a full chart with dosing options was made available in case a clinician wanted to select another statin. Design details like these are often critical to intervention success.23 Future ...
1A), the calyx region shows only weak immunoreactivity but signal intensity increases towards the distal parts of the lobes, where strong immunolabeling can be detected. In R. maderae, orcokinin-immunoreactive processes from extrinsic neurons innervate the basal parts of the calyces, the peduncle ...
Statins, commonly used to treat hypercholesterolemia, have also been proposed as anti-cancer agents. The identification of a predictive marker is essential. The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR), which is inhibited by statins, might
In patients with or at risk for atherosclerotic vascular disease, statins reduce the incidence of major adverse cardiovascular events, but the majority of US adults with an indication for statin therapy are not prescribed statins at guideline-recommended intensity. Clinicians' limited time to address ...
Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, Davignon J, Erbel R, Fruchart JC, Tardif JC, et al.: Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA 2006,295(13):1556–1565. CrossRef Nissen SE,...
The ASTEROID trial even showed regression of coronary atherosclerosis with very high-intensity statin therapy (Nissen et al., 2006). Similarly, Yu et al. showed that intensive but not regular-dose atorvastatin therapy resulted in regression of carotid atherosclerotic disease (Yu et al., 2007) and...
High-intensity statin therapy is associated with a higher rate of transaminase elevations, but no hepatic failure, a very small risk of myopathy, and an increased risk of developing diabetes. However, the small increase in the risk of developing diabetes is much smaller than the marked lowering ...