Accordingly, we designed the ASTEROID trial (A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden) to examine the effects of high-intensity statin therapy on IVUS-derived measures of coronary disease progression. Rosuvastatin is the most recently ...
CYP3A4*1B and CYP3A5*3 SNPs significantly impact the response of Egyptian candidates to high-intensity statin therapy to atorvastatin Mohammed G. Maslub, Nur Aizati Athirah Daud, Mahasen A. Radwan, Abubakar Sha’aban & Arafa G. Ibrahim European Journal of Medical Research volume 29,...
Finally, statin orders were preselected on the basis of the patient’s risk (moderate or high intensity), and a full chart with dosing options was made available in case a clinician wanted to select another statin. Design details like these are often critical to intervention success.23 Future ...
Forty-eight of 86 patients requiring statins were placed on the correct intensity statin using the 2013 guidelines. Regardless of which guideline, a majority of patients required statin therapy.A moderate agreement was found between both guidelines in terms of statin use when applied to an patient...
In patients with or at risk for atherosclerotic vascular disease, statins reduce the incidence of major adverse cardiovascular events, but the majority of US adults with an indication for statin therapy are not prescribed statins at guideline-recommended intensity. Clinicians' limited time to address ...
The mean intensity values were normalised by the maximum image intensity in the area outside of the channel (Imax), i.e. I∗=Iraw/Imax, and expressed in terms of 1−I∗ so that darker regions correspond to higher cell concentration and zero cell concentration corresponds to the ...
The ASTEROID trial even showed regression of coronary atherosclerosis with very high-intensity statin therapy (Nissen et al., 2006). Similarly, Yu et al. showed that intensive but not regular-dose atorvastatin therapy resulted in regression of carotid atherosclerotic disease (Yu et al., 2007) and...
The expression of HMGCR was evaluated based on cytoplasmic intensity using a four-grade scale; negative, weak, moderate, and strong. After the annotation, the strongly stained group of tumors was merged with the moderately stained group due to the low number of patients with strongly stained ...
(2010) PCSK9: The functional relevance of fenofibrate-statin combination therapy to reduce residual cardiovascular risk . Int J Diab Mellitus 30, December [Epub ahead of Print].Jean-Charles Fruchart . (2015) PCSK9: The functional relevance of fenofibrate–statin combination therapy to reduce ...
Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, Davignon J, Erbel R, Fruchart JC, Tardif JC, et al.: Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA 2006,295(13):1556–1565. CrossRef Nissen SE,...