A systematic review and meta-analysis of the role of statins and their intensity in peripheral artery diseaseFUNDING ACKNOWLEDGEMENTS. Type of funding sources: None. BACKGROUND. Peripheral artery disease (PAD) affects more than eight million Americans. However, several studies have shown that those ...
A total of 193 (41.1%) patients were receiving statins prior to admission and the specific statin that was administered and its dose details are listed in Table 1. The intensity of statin treatment of the 178 patients with known dose was as follows: 28 patients (15.7% of the statin group...
Statins reduce cardiovascular risk when used for primary prevention in elderly individuals, but their use, particularly in high doses, requires clinical judgment and an individualized approach Statins should be used for primary prevention of ischaemic stroke and transient ischaemic attack, at least in ...
The crude risk estimates from the individual studies are plotted along with their associated 95% confidence intervals. LDL-C = low-density-lipoprotein cholesterol. Study acronyms: 4S = Scandinavian Simvastatin Survival Study; WOSCOPS = West of Scotland Coronary Prevention Study; CARE = Cholesterol ...
[49]. Cantini et al. found that high-intensity statins enhanced the clinical activity of programmed death receptor-1 (PD-1) inhibitors in patients with malignant pleural mesothelioma and advanced non-small cell lung cancer [69]. Han et al. found that simvastatin may improve the efficacy of ...
an increasing body of evidence suggests their potential as effective therapeutic agents for IVDD. This review summarizes the pleiotropic effects of statins and explores their potential mechanisms and actions in IVDD, with particular emphasis on changes in the expression of relevant molecular markers. Furt...
The next step, researchers said, is to find out why some patients who should be on high-intensity statins are not. They hope doctors will take their study's results into consideration when prescribing statins. "There are a lot of guidelines and recommendations out there, so I think we also...
Protective role of statins in COVID 19 patients: importance of pharmacokinetic characteristics rather than intensity of action. Intern Emerg Med. 2020;15(8):1573–6. 28. Noor FM, Islam MM. Prevalence and associated risk factors of mortality among COVID-19 patients: a meta-analysis. J ...
A double-blind, randomised-controlled trial of moderate-intensity atorvastatin among 364 men who underwent radical prostatectomy reported a null association with PSA levels over time, with the primary endpoint biochemical recurrence at 1 year (hazard ratio 1.00, 95% CI 0.71–1.41), and following up...
As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of their lipid-lowering effects. Among them, the anti-cancer properties of