Patients Between November 2002 and October 2003, 507 patients had a baseline IVUS examination and received at least 1 dose of study drug. After 24 months, 349 patients had evaluable serial IVUS examinations. Intervention All patients received intensive statin therapy with rosuvastatin, 40 mg/d. Mai...
intensity statin and compare admission statin to the discharge statin prescriptionThe findings of this review will be used to assist in modifying protocols that promote appropriate statin dosing for secondary prevention in high-risk coronary artery disease patients.Methods:Conduct a retrospective chart ...
All the patients were candidates for high-intensity statin therapy. The participants were either predisposed to or already had atherosclerotic cardiovascular disease (ASCVD). Approximately two-thirds (62%) of the subjects were on low-dose aspirin as a prophylactic therapy for CVD events. None of ...
Finally, statin orders were preselected on the basis of the patient’s risk (moderate or high intensity), and a full chart with dosing options was made available in case a clinician wanted to select another statin. Design details like these are often critical to intervention success.23 Future ...
1A), the calyx region shows only weak immunoreactivity but signal intensity increases towards the distal parts of the lobes, where strong immunolabeling can be detected. In R. maderae, orcokinin-immunoreactive processes from extrinsic neurons innervate the basal parts of the calyces, the peduncle ...
The ASTEROID trial even showed regression of coronary atherosclerosis with very high-intensity statin therapy (Nissen et al., 2006). Similarly, Yu et al. showed that intensive but not regular-dose atorvastatin therapy resulted in regression of carotid atherosclerotic disease (Yu et al., 2007) and...
Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, Davignon J, Erbel R, Fruchart JC, Tardif JC, etal: Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA. 2006, 295 (13): 1556-1565. 10.1001/jama.295.13....
An H-score was calculated based on the extent and intensity of cytoplasmic or nuclear staining where appropriate (H-score=3 × % of strongly staining cytoplasm+2 × % of moderately staining cytoplasm+1 × % of weakly staining cytoplasm, giving a range of 0–300) (McCarty et al, 1986). ...
High-intensity statin therapy is associated with a higher rate of transaminase elevations, but no hepatic failure, a very small risk of myopathy, and an increased risk of developing diabetes. However, the small increase in the risk of developing diabetes is much smaller than the marked lowering ...
High-dose statin therapy (HIST) halts coronary plaque progression [2]. In addition, when achieving LDL levels of <70 mg/dL, statin therapy has the ability to reduce plaque burden, as documented in randomized controlled trials using intravascular ultrasound (IVUS) of the coronary arteries [2,3...