In addition, the alterations in cellular metabolism observed in our cellular model were restored by interfering with the enhanced SHH signal transduction in sPD. Thus, inhibiting overactive SHH signaling may have potential as neuroprotective therapy during early stages of sPD....
Atomic-level in-cell protein NMR A newly developed method allows structure elucidation of proteins inside intact mammalian cells, using solid-state NMR spectroscopy. Arunima Singh Research Highlights30 Jul 2019Nature Methods Volume: 16, P: 676 ...
Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopyHuan Tan a bYongxiang Zhao a bWeijing Zhao aHuayong Xie aYanke Chen aQiong Tong a cJun Yang a c
During the life cycle of a membrane protein its molecular structure may change and for aggregated proteins this process may be observed on the supramolecul... ML Rütz,DF Hülser - 《European Journal of Cell Biology》 被引量: 46发表: 2001年 Regulation of connexins by the ubiquitin system: ...
The X-ray diffraction analysis of N-(methyl 3,4,6-tri-O-acetyl-2-amino-2-deoxy-β-D-glucopyranoside)-N′-carbamoyl-D-valine ethyl ester has been performed establishing that molecules are associated by two types of NH…O hydrogen bonds. T... R Anulewicz,I Wawer,B Piekarska-Bartosze...
of cells within these germ layers then become progressively restricted to single differentiated cell types characteristic of that germ layer. Conrad Waddington famously depicted this process as a topological landscape [1]. In his model, a ball positioned at the top of the landscape represents a ...
Scientists have used drug modification to adjust the release rate of drugs to an ideal constant rate of release. For example, some scholars have combined two types of preservatives, including one that is hydrolyzable, as a template to prepare pH-sensitive mesoporous silica-based nanocontainers with...
State-of-the-art of membrane flux enhancement in membrane bioreactor O. Kulesha, Z. Maletskyi & H. Ratnaweera | Mutiu Kolade Amosa (Reviewing editor) Article: 1489700 | Received 23 Mar 2018, Accepted 13 Jun 2018, Published online: 13 Jul 2018 Cite this article https://doi.org...
Statistical comparison of means by two-way ANOVA post hoc Tukey, p-values represented as */# < 0.05, **/## < 0.01, ***/### < 0.001, ***/### < 0.0001. Full size image Quantification of endothelial cell cycle states in the P6 retinal vasculature revealed a transit...
Neurotransmitter release is mediated by proteins that drive synaptic vesicle fusion with the presynaptic plasma membrane. While soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs) form the core of the fusion apparatus, additional proteins play key roles in the fusion pathway. ...