This knowledge will allow the construction of designer organisms for process application using biotransformation and fermentative approaches making effective use of single enzymes, whole microbial and even higher cells. 展开 关键词: Metabolomics Metabolome Microbial LC-MS GC-MS Mass spectrometry ...
Study of Energy-Metabolism Enzymes and the State of the Cardiovascular System in Elderly and Senile-Aged Patientsgerontological age groupspyruvate kinaselactate dehydrogenaseblood pressureelectrocardiographyThe present work presents data on the activity of pyruvate kinase (PK), lactate dehydrogenase (LDH), ...
In addition, the alterations in cellular metabolism observed in our cellular model were restored by interfering with the enhanced SHH signal transduction in sPD. Thus, inhibiting overactive SHH signaling may have potential as neuroprotective therapy during early stages of sPD....
the transportation and make metabolism difficult in the vascular system. For BHb, both of the two particles shown very high binding tendency, indicated the positive cooperatives effects. The binding with hemoglobin may influence the oxygen-carrying capacity of blood. These will promote the ...
Limited research has been conducted on energy fluctuation during the transition state, despite the critical role of energy supply in microbial physiological metabolism.This study aimed to investigate the regulatory function of transition state transcription factor AbrB on energy metabolism in Bacillus licheni...
In light of the broad spectrum of products containing nanosilver, the harmfulness of nanosilver to human health and the environment was intensively discuss
. These cells tightly bind together to prevent paracellular drug transport across the BBB and contribute to the high transendothelial resistance (TEER) that limits the passive diffusion of external compounds between the brain and blood [8,9]. Both pericytes and astrocytes play a supporting role in...
Hence NPs may or may not pursue the predictable absorption/distribution/metabolism/excretion i.e ADME model in the host. For example, nanomaterials generally have longer maximal half-lives than traditional counterparts extending to years in some tissues [29]. These NPs can change their properties ...
Metabolomics data demonstrated that purine metabolism was the top pathway in the DTPCs compared with the parental cells. The changes in purine metabolites in the DTPCs were partially rescued by targeting miR-21. Analysis of protein levels in the DTPCs showed that reduced expression of ...
Laboratory Investigation (2018) 98, 164–174 © 2018 USCAP, Inc All rights reserved 0023-6837/18 EDITORIAL The NDPK/NME superfamily: state of the art Mathieu Boissan1,2, Uwe Schlattner3 and Marie-Lise Lacombe1 Nucleoside diphosphate kinases (NDPK) are nucleotide metabolism enzymes encoded by...