The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease. Cell Metab. 16, 290–295 (2012). CAS PubMed Google Scholar Harmel, R. & Fiedler, D. Features and regulation of non-enzymatic post-tran
of enzymes known as dihydroceramide synthases. In addition, alterations in ceramide synthesis, trafficking and metabolism in specific cellular compartments exert distinct consequences on metabolic homeostasis. Here, we examine the emerging concept of how the intracellular localization of ceramides with ...
Molecular mechanism and application of emerging technologies in study of bacterial persisters. BMC Microbiol. 24, 480 (2024). Article PubMed PubMed Central Google Scholar Paul, P., Sahu, B. R. & Suar, M. Plausible role of bacterial toxin–antitoxin system in persister cell formation and ...
The shift between oxidative phosphorylation and glycolysis is mainly regulated by the AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR) pathways. Chondrocyte metabolic changes are likely to be a feature of different OA phenotypes. Determining the role of chondrocyte ...
Metabolic reprogramming of immune cells and somatic cells alike has a role in perpetuating disease in the joints. In this Review, the authors examine metabolic alterations that occur in the main cells of the joint tissues during osteoarthritis. Metabolis
The metabolic substrate produced by the autophagy cycle participates in the production of metabolites to maintain cell growth, which is essential for tumor growth, invasion, metastasis and drug resistance. However, the mechanism is not clear. The aim of our work is to summarize the role of ...
Recent study has indicated that the chemo-resistant breast cancer cells and mesothelioma cells have high levels of aldehyde dehydrogenase (ALDH) activity. ALDH is an important detoxifying enzyme of glycolysis, which belongs to a class of detoxifying enzymes whose expression is linked to cancer chemo-...
The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital ma
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release
A quantitative understanding of how pathway context shapes sequence and activity would assist in the interpretation of disease-associated mutations, the design of new enzymes, and directing the laboratory evolution of metabolic pathways. In this work, we examine the residue-level epistatic interactions ...