This phenomenon also leads to an increase in metabolic intermediates for the biosynthesis of inflammatory and degradative proteins, which in turn activate key transcription factors and inflammatory signalling pathways involved in catabolic processes, and the persistent perpetuation of drivers of pathogenesis. ...
Genetic toxicology of flavonoids: The role of metabolic conditions in the induction of reverse mutation, SOS functions and sister-chromatid exchanges While in the Ames assay the mutagenicity of quercetin is enhanced by the presence of rat liver microsomal enzymes (S9) or the respective cytosolic frac...
In this chapter, we review the roles of these bioactive sphingolipids and their metabolic enzymes in colitis, colitis associated cancer, and colorectal cancer. 展开 关键词: Colon cancer Inflammatory bowel disease Cyclooxygenase 2 Signal transducer and activator of transcription 3 Sphingosine kinase ...
Cellular metabolic status and mammalian gene expression interact under the critical regulation of various signaling pathways, transcription factors (TFs), and epigenetic remodelers that affect cell fate during development [10,11,12,13]. Each cell type in the brain has a distinct metabolic profile and...
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release
of enzymes known as dihydroceramide synthases. In addition, alterations in ceramide synthesis, trafficking and metabolism in specific cellular compartments exert distinct consequences on metabolic homeostasis. Here, we examine the emerging concept of how the intracellular localization of ceramides with ...
Ferroptosis involves various metabolic processes, including iron, lipid and glutathione metabolism. Both in vitro and in vivo evidence supports the pathophysiological role of ferroptosis in myocardial ischaemia–reperfusion injury, anthracycline-mediated cardiotoxicity, sepsis‑induced heart injury, hypertrophic...
Recent study has indicated that the chemo-resistant breast cancer cells and mesothelioma cells have high levels of aldehyde dehydrogenase (ALDH) activity. ALDH is an important detoxifying enzyme of glycolysis, which belongs to a class of detoxifying enzymes whose expression is linked to cancer chemo-...
The metabolic substrate produced by the autophagy cycle participates in the production of metabolites to maintain cell growth, which is essential for tumor growth, invasion, metastasis and drug resistance. However, the mechanism is not clear. The aim of our work is to summarize the role of ...
The role of neutrophils in solid tumor metastasis remains largely controversial. In preclinical models of solid tumors, both pro-metastatic and anti-metastatic effects of neutrophils have been reported. In this study, using mouse models of breast cancer, we demonstrate that the metastasis-modulating ...