参考资料：1.Patrick T Gunning et.al; A STAT inhibitor patent review: progress since 2011. DOI:10.1517/13543776.2015.1086749.2.Jiang-Jiang Qin et al;Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation.J. Med. ...
参考资料: 1.Patrick T Gunning et.al; A STAT inhibitor patent review: progress since 2011. DOI:10.1517/13543776.2015.1086749. 2.Jiang-Jiang Qin et al;Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation.J. Med. ...
AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM 靶点活性 STAT6:21 nM 体外活性 AS1517499具有强大的STAT6抑制作用,IC50值为21 nM。它还能抑制小鼠脾脏T细胞在IL-4诱导下向Th2分化的过程,其IC50值为2.3 nM,同时不影响IL-12诱导的辅助性T细胞1(Th1)分化。AS1517499选择性地抑制Th2分化,而不影响...
1.Patrick T Gunning et.al; A STAT inhibitor patent review: progress since 2011. DOI:10.1517/13543776.2015.1086749. 2.Jiang-Jiang Qin et al;Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation.J. Med. Chem. 2021...
纯度规格:99.67%产品类别:抑制剂 货号:T79185 Product Introduction Bioactivity 名称STAT6-IN-2 描述STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits eotaxin-3 secretion, induces STAT6 reporter luciferase activity in 293-EBNA cells, and inhibits tyrosine phosphorylation of STAT6. ...
The STAT6 inhibitor space has become a hotspot for heavy investment by multinational pharmaceutical companies in the autoimmune field. According toFrost & Sullivan, the global autoimmune drug market is expected to reach$176 billion by 2030, with a compound annual growth rate of3.6%from 2022 to 20...
[54]. Although studies supported that ferroptosis offers new perspective for the treatment of ALI, whether it is widely existed in most of ALI and its detail regulatory mechanism remains unclear. In this study, Ferr-1 and DFO, as classical inhibitor of ferroptosis, were both used to confirm ...
[2] Chiba Y, et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am J Respir Cell Mol Biol. 2009 Nov;41(5):516-24. HB221111
1.Patrick T Gunning et.al; A STAT inhibitor patent review: progress since 2011. DOI:10.1517/13543776.2015.1086749. 2.Jiang-Jiang Qin et al;Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation.J. Med. Chem. 2021...
PROBLEM TO BE SOLVED: To provide a STAT 6 (signal transducer and activator of transcription 6) activation inhibitor that exactly inhibits STAT 6 activation.DOI TAKESHI土肥 武SUDA MAKOTO須田 誠MORIKAWA SHIGERU森川 滋KITAMURA TAKAHIRO北村 崇博