AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM 靶点活性 STAT6:21 nM 体外活性 AS1517499具有强大的STAT6抑制作用,IC50值为21 nM。它还能抑制小鼠脾脏T细胞在IL-4诱导下向Th2分化的过程,其IC50值为2.3 nM,同时不影响IL-12诱导的辅助性T细胞1(Th1)分化。AS1517499选择性地抑制Th2分化,而不影响...
AS 1517499 is a potent STAT6 inhibitor (IC50= 21 nM).In vitro, it inhibits IL-4-induced Th2 differentiation of mouse spleen T cells (IC50= 2.3 nM), without influencing Th1 differentiation induced by IL-12. In a mouse model of allergic bronchial asthma, treatment with AS 1517499 reduces ...
A novel STAT6 inhibitor AS1517499 ameliorates an 18、tigen-induced bronchial hypercontractility in mice. Am J Respir CellMol Biol. 2009 Nov;41(5):516-24.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax:E-mail: ...
[2] Chiba Y, et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am J Respir Cell Mol Biol. 2009 Nov;41(5):516-24. HB221111
AS1517499是一种有效的STAT6抑制剂,IC50为21nM。注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!CAS号:919486-40-1纯度:99.17%分子式:C20H20ClN5O2分子量:397.86结构式:储存条件:-20℃,有效期2年,溶入溶剂后-20℃请尽量在一个月内使用。相关搜索:STAT6抑制剂(AS1517499),919486-40-1...
AS1517499, a selective signal transducer and activation of transcription 6 (STAT6) inhibitor, has been shown to effectively block this connection. In this study, we further explored the underlying mechanism by constructing an AD mouse model. Methods:Female BALB/c mice were randomly divided into ...
1.Patrick T Gunning et.al; A STAT inhibitor patent review: progress since 2011. DOI:10.1517/13543776.2015.1086749.2.Jiang-Jiang Qin et al;Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation.J. Med. Chem. ...
To this end, we observed that the STAT6 inhibitor AS1517499 sensitized MHH-ES-1 cells to either SN-38 (Fig. 8a) or etoposide (Fig. 8b) in vitro. Similarly, filgotinib enhanced either SN-38 (Fig. 8c, d) or etoposide (Fig. 8e, f)-induced MHH-ES-1 or TC-71 cell death in ...
1.Patrick T Gunning et.al; A STAT inhibitor patent review: progress since 2011. DOI:10.1517/13543776.2015.1086749. 2.Jiang-Jiang Qin et al;Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation.J. Med. Chem. 2021...
Using the STAT6-specific inhibitor AS1517499 we could confirm the role of STAT6 in increasing colony-forming frequency. However, clonogenic recovery assays revealed that interleukin-4 does not rescue the effects of either irradiation or docetaxel treatment. We therefore propose that although the ...