Protein inhibitor of activated STAT1 (PIAS1) is phosphorylated by IKKα at Ser90 in a PIAS1 E3 ligase activity-dependent manner. Whether PIAS1 is also phosphorylated at other residues and the functional significance of these additional phosphorylation events are not known. The transcription factor ...
2.3Protein inhibitor of activated STAT (PIAS) The activity ofSTAT proteinscan be regulated independently of its phosphorylation state involving a family of proteins named PIAS. The PIAS family comprises a minimum of five members (PIAS1, PIASxα, PIASxβ,PIAS3, and PIASy) in mammals...
Protein inhibitor of activated STAT1 (signal transducer and activator of transcription 1) (PIAS1) was identified as a cellular protein binding to N. PIAS1 is known to bind to p65 (RelA) in the nucleus and blocks its DNA binding, thus functions as a repressor of NF-κB. Binding of N to...
Shuai K (2006) Regulation of cytokine signaling pathways by PIAS proteins. Cell Res 16(2):196–202 Article PubMed CAS Google Scholar Niu GJ et al (2018) Protein inhibitor of activated STAT (PIAS) negatively regulates the JAK/STAT pathway by inhibiting STAT phosphorylation and translocation. ...
protein inhibitor of activated STAT protein 1 protein inhibitor of activated STAT x protein inhibitor of activated STAT, 1 protein inhibitor of activated STAT, 21 2 protein inhibitor of activated STAT-1 protein inhibitor of activated STAT1 protein inhibitor of activated STAT2 Protein Inhibitor of Act...
The protein inhibitor of activated STAT1 (PIAS1), known to be a small ubiquitin-like modifier (SUMO) E3 ligase, was found to interact with the human cytomegalovirus IE2 protein. We found that the sumoylation of IE2 was markedly enhanced by wild-type PIAS1 but not by a mutant containing ...
Protein inhibitor of activated STAT3 (PIAS3) is the key negative regulator of JAK/STAT3 signalling. However, its effect on atherogenesis is unknown. Here, we observed that PIAS3 levels are reduced in atherosclerotic lesions and that PIAS3 expression decreases in conjunction with increases in ...
protein inhibitor of activated STAT1 protein kinase protein kinase B protein kinase C protein kinases protein kinesis protein malnutrition protein metabolism protein p53 protein phosphatases protein quotient protein restriction protein S protein S deficiency protein shock protein shock therapy protein splicing ...
BSO, a specific and irreversible inhibitor of GCL, deletes GSH and inhibits the differentiation of 3T3-L1 preadipocytes and preadipocytes derived from the SVF of inguinal as well as epididymal fat pads [243]. BSO inhibits adipocyte differentiation through inhibition of MCE via downregulation of ...
protein inhibitor of activated STAT TcPTP T cell protein tyrosine phosphatase MEF mouse embryonic fibroblast IFN interferon GST glutathione S-transferase PIPES 1,4-piperazinediethanesulfonic acid ISG interferon-stimulated gene MTA methylthioadenosine MDA N-methyl- 2-deoxyadenosine STAT1 (signal transducers ...