In the current study, we demonstrated that upregulated TGF-beta may promote epithelial-mesenchymal transition (EMT) through STAT3 activation. In addition, we explored the contributions of STAT3 to HNSCC with a specific focus on its transcriptional regulation and its interaction with the long non...
应用AG490治疗后,TGF-β1的表达下降,说明JAK-STAT信号通路的特异性抑制剂AG490可以抑制JAK信号通路的激活,拮抗TGF-β1的表达,从而阻止肾组织的进一步损伤。 综上所述,AG490可能通过TGF-β1来阻断JAK/STAT3信号通路的激活,进而抑制创伤性休克肾损伤的发展,JAK/STAT3信号通路的激活有可能成为治疗创伤性休克肾损伤的一个...
6. Yin, W. et al. BBB-penetrating codelivery liposomes treat brain metastasis of non- small cell lung cancer with EGFR(T790M) mutation. Theranostics 10, 6122–6135 (2020). 7. =Wang, H. et al. TGF-beta1-induced...
Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling Nat. Med., 11 (2005), pp. 845-852 CrossrefView in ScopusGoogle Scholar [69] Z. Wei, X. Jiang, H. Qiao, B. Zhai, L. Zhang, Q. Zhang, Y. Wu, H. Jiang, X. Sun ...
Woosley AN, Dalton AC, Hussey GS, Howley BV, Mohanty BK, Grelet S, Dincman T, Bloos S, Olsen SK, Howe PH. TGF beta promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis. Oncogene. 2019;38:3794–811. ...
Secretomic analysis also showed that decreased NAD triggered interleukin-6 and transforming growth factor beta (TGFβ) secretion, which activated integrin-β-catenin, TGFβ-MAPK, and inflammation signaling pathways to sustain the signaling required for EMT. We further revealed that decreased NAD ...
In tumor cellsper se, hyperactivated STAT3 decreases the expression of immune-stimulating factors including interferons (IFNs), pro-inflammatory cytokines (IL-12, TNF-α) and chemokines (CCL5, CXCL10), while increases the expression of certain cytokines and growth factors (IL-6, IL-10, TGFβ...
2017. Targeted blockade of TGF-beta and IL-6/JAK2/STAT3 pathways inhibits lung cancer growth promoted by bone marrow-derived myofibroblasts. Sci Rep. 7:8660.J. Shi, J. Feng, J. Xie, Z. Mei, T. Shi, S. Wang, et al., Targeted blockade of TGF-β and IL-6/JAK2/STAT3 pathways ...
TGF-beta 1 reciprocally controls chemotaxis of human peripheral blood monocyte-derived dendritic cells via chemokine receptors. J. Immunol. 164, 2285–2295 (2000). Article CAS PubMed Google Scholar Gabrilovich, D. et al. Vascular endothelial growth factor inhibits the development of dendritic cells...
[2] Lin L, et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28(7): 961-972(2009). [3] Pang M, et al. A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in ...