[1] Mertens C, Haripal B, Klinge S, et al. Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity[J]. P Natl Acad Sci, 2015, 112(48): 14811-14816. [2]...
[1]Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.Science. 1994;264:1415–21. [2]Song L ,Rawal B ,Nemeth J A ,et al. JAK1 activates STAT3 activity in non-small-cell lung cancer cells an...
STAT3信号通路调控小鼠胚胎植入后组织扩张的分子机制研究 《Cell Reports》:STAT3 signaling enhances tissue expansion during postimplantation mouse development 编辑推荐: 本研究发现STAT3缺失导致小鼠胚胎发育延迟,并揭示STAT3丝氨酸727位点磷酸化(pS727)在植入后外胚层扩张中的主导作用。通过单细胞测序(scRNA-seq)和嵌合...
[11]Ma JH, Qin L, Li X. Role of STAT3 signaling pathway in breast cancer. Cell Commun Signal. 2020 Feb 28;18(1):33. [12]Mohan C D, Rangappa S, Preetham H D, et al. Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature[J]. Semin Cancer Biol, 2020,...
IL-6/JAK/STAT3 signaling pathway[1] STAT3抑制剂研究进展 鉴于STAT3在肿瘤发生发展中的关键作用,以STAT3为靶点进行药物开发已成为近二十年来主要的药物研究热点之一。目前已有许多化合物被报道具有STAT3相关通路抑制活性,许多药物已进入临床。下图显示了目前处于临床研究阶段的部分STAT3抑制剂,适应症包括肝癌、结直肠癌、...
STAT3在一些病毒感染中表现出前病毒功能(例如HBV、HCV、HSV-1、水痘带状疱疹病毒、HCMV、麻疹病毒),而在另一些病毒感染中起抗病毒作用(例如肠道病毒71、SARS病毒、hMPV)。 STAT3的异常激活与多种人类肿瘤的进展和不良预后有关(例如乳腺癌...
STAT3/TGFBI 信号通路:揭开胶质母细胞瘤替莫唑胺耐药之谜 《Cancer Cell International》:STAT3/TGFBI signaling promotes the temozolomide resistance of glioblastoma through upregulating glycolysis by inducing cellular senescence 编辑推荐: 为解决胶质母细胞瘤(GBM)替莫唑胺(TMZ)耐药及细胞衰老机制不明的问题,研究...
提出可以通过IL6/JAK2/STAT3信号通路调控小胶质细胞表型,探索了新的潜在的预防和治疗方法。 参考文献: Jin, Y., et al., Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis. Signal Transduct Target Ther, 2022. 7(1): p. 52....
et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nature Med. 11, 1314–1321 (2005). Article CAS PubMed Google Scholar Yu, H., Kortylewski, M. & Pardoll, D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour ...
OPEN Cell Death and Differentiation (2017) 24, 1761–1771 Official journal of the Cell Death Differentiation Association www.nature.com/cdd RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation Jawahar Kopparam1, Johanna Chiffelle1, Paolo Angelino2, Alessandra Piersigilli3,4, ...