A clinical trial setting is considered in which two treatments are available for a particular ailment. A two—stage trial is studied, in which patients are randomised equally in the first stage, and the better treatment at the end of this stage is used exclusively in the second stage. For ...
Adaptive design - two-stage method - Bayesian method - optimal stopping time - clinical trialsAmong a variety of adaptive designs, stage-wise design, especially, two-stage design is an important one because patient responses are not available immediately but are available in ...
In some clinical trials, primary chemotherapy has been administered to patients with small volume cancers in an effort to avoid lymph node dissection. Although clinical trials directly comparing lymph node dissection to chemotherapy have not been performed, it appears that primary chemotherapy, when comp...
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The primary objective of a phase II clinical trial of a new drug or regimen is to determine whether it has sufficient biological activity against the disease under study to warrant more extensive development. Such trials are often conducted in a multi- institution setting where designs of more th...
Bexarotene [LGD1069] (Targretin capsules; Ligand Pharmaceuticals Incorporated) (an RXR-selective agonist52) is the first rexinoid to be tested in human clinical trials. In a phase 1 study of patients with advanced cancers, therapy with bexarotene led to responses in 2 of 9 patients with CTCL...
Multi-stage clinical trials are essential for developing effective DTRs, and SMART methodology enables researchers to test various treatment sequences to find the best fit for each patient. Unlike traditional trials, SMART involves multiple stages of treatment, where patients a...
Naiyer A. Rizvi, MD: There are trials obviously ongoing in limited-stage small cell lung cancer with immunotherapy. Some of these patients can actually do very well with just chemotherapy and radiation, as Taofeek pointed out. Patients who have pre-existing paraneoplastic syndromes. You know, ...
Mesothelioma clinical trials give hope to stage 3 patients who can’t have surgery. They offer new treatments that might improve prognosis and life expectancy. Patients should talk to their doctors about clinical trials in their area. Get Help Finding a Top Mesothelioma Doctor Near You Find a Do...
Clinical trials include:WSG and AGO-Mamma Intergroup Study: Randomized phase III trial o... BC Online - 《Breast Cancer Online》 被引量: 18发表: 2006年 加载更多 研究点推荐 axillary nodal ratio neoadjuvant chemotherapy stage II/III breast cancer 站内活动 ...