A clinical trial setting is considered in which two treatments are available for a particular ailment. A two—stage trial is studied, in which patients are randomised equally in the first stage, and the better treatment at the end of this stage is used exclusively in the second stage. For ...
This confirms anticancer activity of Panagen. ClinicalTrials.gov NCT02115984 from 04/07/2014. 展开 关键词: Breast cancer FAC chemotherapy AC chemotherapy Disease-free survival dsDNA CD8 + perforin + T cells DOI: 10.1186/s12885-016-2711-5 被引量: 4 年份: 2016 ...
Clinical trials play an important role in pharmaceutical development. Therefore, how to effectively shorten the testing time and reduce the cost is what we need. A two-stage design can effectively shorten the testing time and reduce the cost in the pharmaceutical development for phase studies. ...
An adaptive Simon Two-Stage Design for Phase 2 studies of targeted therapies The field of specialized medicine and clinical development programs for targeted cancer therapies are rapidly expanding. The proposed Phase 2 design allows... CL Jones,E Holmgren - 《Contemporary Clinical Trials》 被引量:...
Simon's optimal two-stage design is widely used to conduct single-dose phase II clinical trials. We extend this basic methodology to the situation where the researcher desires to test an experimental drug for activity at a low dose level, but is willing to increase the dose part-way through...
Seshan, VE. 2018. “Clinfun: Clinical Trial Design and Data Analysis Functions.” Software.https://CRAN.R-project.org/package=clinfun. Simon, R. 1989. “Optimal Two-Stage Designs for Phase II Clinical Trials.”Controlled Clinical Trials10 (1): 1–10.https://doi.org/https://www.doi.or...
Adaptive two-stage sampling in clinical trialsAdaptive two-stage sampling in clinical trialsPlay-the-winner ruleStopping rulesSequential designProbability of correct selectionA class of two stage adaptive sampling schemes for comparing the success rates of two treatments in a clinical trial is defined. ...
duration of response, overall survival, time to response, disease control rate, investigator-assessed ORR, pharmacokinetics, immunogenicity and safety. The trial will enroll approximately 80 patients across Asia, Europe and North America. For more information about this...
NAYA Oncologyaims to achieve clinical proof-of-concept for its two bispecific antibodies acquired from Cytovia Therapeutics, with the goal of advancing towards breakthrough outcomes for Hepatocellular Carcinoma and Multiple Myeloma patients. Clinical tri...
Boston, Mass., March 2, 2009-WorldCare Clinical, LLC (WCC), a leading imaging CRO for clinical trials in the pharmaceutical, biotechnology, and medical device industries, today introduced a new service offering to support sponsors conducting early-stage and Phase II clinical trial...