In some situations, when the prognostic value of a test has been established as sufficiently robust in retrospective studies, the test can be used in a prospective clinical trial to limit the group of patients who should be randomized. An example of such a situation is provided by the TAILORx...
Artificial intelligence (AI) technology, combined with big data, hold the potential to solve many key clinical trial challenges. Real World Data Late phase research, technology solutions and access to RWD are at the forefront of creating efficiencies in all stages of study design and implementation...
Review Article06 Jan 2025 Treatment advances across the cervical cancer spectrum In this Review, the authors discuss key clinical trials and therapeutic advances that have informed the current treatment landscape for cervical cancers of all stages, including refinement of surgical management approaches, th...
Numerous small molecules or compounds are currently in clinical trials for fibrosis. Published clinical data on these compounds were listed in Table1, and we categorized these drugs by targets and then ranked each target drug by clinical trial grade (marketed, phase 3, phase 2, and phase 1). ...
For instance, if a single trial pools different stages of disease or different diseases in which different distinct disease manifestations predominate, separate well-defined outcome assessments may be needed because of the different aspects of feeling and functioning and the concepts of interest in ...
Non-dialysis CKD (stages 1–5) Physical activity and exercise1.1 We recommend physical activity should be encouraged in the non-dialysis CKD population without contraindications and with stable, controlled comorbidities (1B). 1.2 We recommend non-dialysis CKD patients follow the UK Chief Medical ...
The indications shall be described. This includes the stages and/or severities of the pathologies, the specificmedical conditions, and the specific anatomical locations or confirmation that no anatomical locations are contraindicated, as applicable. The target population(s) shall be specified, for exampl...
This phase comprised 3 stages: 1. Testing of the original information sheet. The information was tested using participants who were instructed to imagine receiving treatment for leukemia and being asked to take part in a trial to test different drug treatments. They were posted the sheet so tha...
role in different tumor stages. For example, the mutations ofNFE2L2were mainly gain-of-function and had been proved to increase the drug or radiation resistance in ESCC40,41. This alteration could bring a significantly bad impact on late-stage patients whose major anti-tumor therapies were che...
1. There are two stages in the problem-solving process: a preliminary stage and a main one. The preliminary stage serves as a data preprocessing. It focuses on the formation of representative feature space and the evaluation of the expected return, which is required to calculate the target ...