SREBP1是重要的脂代谢转录因子,上调其水平可优先激活下游脂肪酸合成相关基因[25],使脂质合成增加,其中乙酰辅酶A羧化酶1(acetyl-CoA carboxylase 1,ACC1)、脂肪酸合成酶(fatty acid synthase,FASN)为脂肪酸合成的关键限速酶,硬脂酰辅酶...
Reciprocal regulation of the human sterol regulatory element binding protein (SREBP)-1a promoter by Sp1 and EGR-1 transcription factors. FEBS Lett 2008; 582:177-184.A. Fernandez-Alvarez, G. Tur, G. Lopez-Rodas, M. Casado, Reciprocal regulation of the human sterol regulatory element binding ...
优惠价:点击询价 货号:P34358 名称:pGL3-SREBP1C(mouse)-Promoter-Fluc 别称: 基因长: 规格:默认发少量干粉质粒(现货)大提液体质粒(期货) 质粒宿主:哺乳细胞 质粒用途:荧光素酶报告 片段类型:Promoter 片段物种:小鼠 原核抗性:Amp 筛选标记: 荧光标记:Fluc ...
㊀㊀摘要:目的㊀探讨泡沫细胞ＤＮＡ甲基化及其对脂代谢基因胆固醇调节元件结合蛋白１(ＳＲＥＢＰ１)表达的调控作用ꎮ方法㊀将体外培养的单核细胞系ＴＨＰ￣１采用乙酸酯㊁氧化型低密度脂蛋白等处理后建立泡沫细胞模型ꎬ采用实时荧光定量ＰＣＲ法检测ＴＨＰ￣１单核细胞和泡沫细胞中ＤＮＡ甲基转移酶１(...
The phosphatidic acid phosphatase lipin-1 critically regulates lipid homeostasis, either through its enzymatic activity or by co-regulating gene transcription [217]. Active lipin-1 in the nucleus evokes nuclear eccentricity, reduces SREBP promoter activity, and decreases mSREBP abundance [200]. Phosphory...
the hepatitis B viral enhancer II/pregenomic promoter[J]. J Biol Chem, 1999, 274(5): 2858-2865. DOI: 10.1074/jbc.274.5.2858. [8] Shao W, Espenshade PJ. Expanding roles for SREBP in metabolism[J]. Cell Met...
7 The regulation of pGL3-SCD2 and SCD3 promoter activities by different doses of SREBP1 24 期 韩立强等:奶牛 SREBP1 蛋白在乳腺上皮细胞的表达定位及对 SCD1 基因启动子的转录调控 4803 从 19.90 降低到 10.31,而 pGL3- SCD3 启动子的活性 随着质粒含量的增加则呈现上升趋势,其活性值从 59.81 分别...
However, the SREBP-1c gene is known to have an SREBP1 response element (SRE) in the promoter region as observed in mouse (Amemiya-Kudo et al., 2000) and bovine (Lengi and Corl, 2010). We have analyzed the promoter region of the sheep SREBF1a up to 5,000 bp upstream of the ...
英文别名: pGL3-SREBP1C(mouse)-Promoter-Fluc中文名: 中文别名: CBNumber: CB313365582 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 1 pGL3-SREBP1C(mouse)-Promoter-Fluc化学性质 安全信息pGL3-SREBP1C(mouse)-Promoter-Fluc性质、用途与生产工艺 pGL3-SREBP1C(mouse)-Promoter-...
(originally cloned as ADD1) are protein products of alternative promoter usage of the SREBP-1 gene. The third isoform is transcribed from a different gene, SREBP-2. SREBPs are present as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, the SREBP protein...