Src homology 3 domain of hepatitis C virus NS5A protein interacts with Bin1 and is important for apoptosis and infectivity. Gastroenterology. 2006; 130 :794–809. doi: 10.1053/j.gastro.2005.12.030. [ Cross Ref ]Nanda S.K., Herion D., Liang T.J. The SH3 binding motif of HCV NS5A ...
A protein domain found in many signaling proteins. SH3 domains bind proline-rich regions in other proteins recruiting these other proteins to the signaling complexes (see Adaptors). Signal...doi:10.1007/3-540-27806-0_1377Vohr, Hans-WernerEncyclopedic Reference of Immunotoxicology...
Src‐Homology 3 (SH3) Domainssrc‐homology 3 (SH3) domainsThis article has no abstract. Keywords: src-homology 3 (SH3) domainsdoi:10.1002/0471203076.emm0634Andrea MusacchioEuropean Institute of Oncology Milan ItalyAmerican Cancer Society
c-src homology 3 domains (SH3) modulate the formation of a number of protein complexes that are important in cell signaling and cytoskeletal organization. The SH3 domain is recognized by short conserved proline-rich motifs which adopt left-handed polyproline helices on binding. In order to ...
The Src homology 3 (SH3) domains are a modular structure of about 60 amino acid residues found in many proteins important in signal transduction. Each SH3 domain has a binding specificity to sequences containing a PXXP motif in ligand proteins. We found that a focal adhesion kinase (FAK)-...
Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets. TL Leto,AG Adams,MI De - 《Proceedings of the National Academy of Sciences》 被引量: 709发表: 1994年 Assembly ofthephagocyte NADPH oxidase: Binding ofSrc homology 3domains toproline-rich ...
The v-Crk oncogene product consists of two protein interaction modules, a Src homology 2 (SH2) domain and an SH3 domain. Overexpression of CrkI, the cellular homolog of v-Crk, transforms mouse fibroblasts, and elevated CrkI expression is observed in several human cancers. The SH2 and SH3...
The Src homology domain 3 (SH3)-containing adapter protein SH3 lymphocyte protein 2 (SLy2, also known as hematopoietic adapter-containing SH3 and sterile ±-motif (SAM) domains 1; HACS1) is strongly up-regulated upon B cell activation and functions as an endogenous immunoinhibitor in vivo,...
domain.The catalytic activity of the c-Abl tyrosine kinase is tightly regulated by its Src homology 3 (SH3) domain through a complex mechanism that may involve intramolecular binding to Pro242 in the linker region between the SH2 and catalytic domains as well as interactions with a trans-...
Here we show that CD28 is capable of binding the Src homology 3 (SH3) domains of several proteins, including Grb2. The interaction between Grb2 and CD28 is mediated by the binding of Grb2-SH3 domains to the C-terminal diproline motif present in the cytoplasmic domain of CD28. While ...