The BAR domain superfamily is currently composed of three groups, including the classical BAR whose structure was resolved first (2, 3), the more recently discovered F-BAR (Fes/CIP4 homology BAR), and the I-BAR (inverse-BAR) (1, 4, 5). These three types of domains organize around the...
Here we show that CD28 is capable of binding the Src homology 3 (SH3) domains of several proteins, including Grb2. The interaction between Grb2 and CD28 is mediated by the binding of Grb2-SH3 domains to the C-terminal diproline motif present in the cytoplasmic domain of CD28. While ...
Src consists of 4 functional regions: Src homology 4 domain (SH4), SH3, SH2, SH1 (catalytic domain) and is activated through auto-phosphorylation at tyrosine 416 upon SH3 ligand binding7,8,9. Two main SH3 domain-binding motifs, proline/arginine-rich motifs (PR motifs), have been ...
Blocking the function of tyrosine phosphatase SHP-2 by targeting its Src homology 2 domains. J Biol Chem 2003; 278:42893-42898. 47 Chen L, Wang ZW, Zhu JW, Zhan X. Roles of cortactin, an actin polymerization mediator, in cell endocytosis. Acta Bio- chim Biophys Sin (Shanghai) 2006; ...
Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P et al (1986) Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320:134–139 PubMed CAS Google Scholar Greene GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J (1986) Sequence and ...
The kinase domain of Src is indeed important, and other regions are also important for Src function. Src consists of four distinct domains: the unique, Src homology (SH) 3, SH2, and kinase domains (Figure 1) [30,31]. The unique domain regulates Src localization. In particular, glycine ...
and an intracellular C-terminal domain showing homology to other TM7 superfamily members. The F4/80 antigen is expressed by a majority of mature macrophages and is one of the best markers for this population of cells. However, other cell types, such as peritoneal eosinophils, Langerhans ...
Using glutathione S-transferase (GST) fusion proteins, we found that CD2 bound to the Src homology (SH) 3 domain of Fyn. Interestingly, the CD2-Fyn association was negatively regulated by the Fyn SH2 domain; CD2 bound poorly to GST fusion proteins expressing both the SH2 and SH3 domains ...
The signal transducers and activators of transcription (STATs), which are recruited to the JAK-receptor complex via their Src homology 2 (SH2) domain, are phosphorylated on a conserved tyrosine residue in the C-terminal region. This phosphorylation results in STAT dimerization and forms a protein...
The Phyre protein fold recognition server15indicated that extensive structural homology exists between EspJ and the ADP-ribosyltransferase (ART) domain of thePseudomonas syringaeeffector AvrPphF-ORF2 (ref.16) (E-value=1.3 × 10−8), including the β-sheet fold characteristic of ARTs (Fig. 1a...