A tyrosine phosphatase, SHP-1, that contains src homology 2 (SH2) domains is recognized as a negative regulator for various intracellular signaling molecules, including those downstream of the TCR and the IL-4 receptor. Here we assessed the role of SHP-1 in Th1/Th2 cell differentiation and ...
The polyproline motifs within the C terminus also interact with proteins that contain Src homology 3 (SH3) domains. One such protein, the adaptor protein Grb2, is believed to bind to one or more of the proline-rich stretches of SHIP through one or both of its SH3 domains (1, 3, 14...
Moreover, ICAM-1 lacks the motifs resembling the Src homology domains (SH) that can recruit phosphorylated proteins at the cytoplasmic, membrane-proximal site (16). Nevertheless, Fg-ICAM-1 ligation in Raji B-cells results in proliferative signals that causes 2–3-fold increase in the ...
英文名称:Recombinant Src Homology 2 Domain Containing Adapter Protein B (SHB) 保质期:避免反复冻融。2-8°C不超过一个月,-80°C不超过12个月。 保存条件:2-8°C不超过一个月,-80°C不超过12个月 含Src同源物2域适配蛋白B(SHB)重组蛋白的产生是应用了重组DNA或重组RNA的技术从而获得的蛋白质。目前,...
In particular, two cytoplasmic protein tyrosine phosphatases composed of two Src homology 2 (SH2) NH2-terminal domains and a C-terminal protein-tyrosine phosphatase domain referred to as SHP-1 and SHP-2 are known to govern a host of cellular functions. SHP-1 and SHP-2 modulate progenitor ...
Haefner B, Baxter R, Fincham VJ, Downes CP, Frame MC: Cooperation of Src homology domains in the regulated binding of phosphatidylinositol 3-kinase. A role for the Src homology 2 domain. J Biol Chem. 1995, 270: 7937-7943. 10.1074/jbc.270.14.7937. Article CAS PubMed Google Scholar Mart...
摘要: We have recently identified in SLE sera naturally occurring anti-idiotypic antibodies against antiphosphotyrosine antibodies. Analysis of immunochemical properties of these anti-idiotypic antibodies suggest that they are of beta/gamma type mimicking the antigen.关键词:...
To clarify the role of protein tyrosine phosphatase (PTPase) containing a pair of Src homology 2 (SH2) regions upon insulin signaling, we studied the interactions between the insulin receptor and SH-PTP2 coupled to glutathione-S-transferase. A full length SH-PTP2 was phosphorylated by insulin...
Counteracting effects operating on Src homology 2 domain- containing protein-tyrosine phosphatase 2 (SHP2) function drive selection of the recurrent Y62D ... S Martinelli,AP Nardozza,SD Vigne,... - 《Journal of Biological Chemistry》 被引量: 10发表: 2012年 Making Sense of Missense Mutations ...
Proteins with Src homology 2 (SH2) domains play major roles in tyrosine kinase signaling. Structures of many SH2 domains have been studied, and the regions... H Tanaka,KI Akagi,C Oneyama,... - 《Journal of Biological Chemistry》 被引量: 32发表: 2013年 Rapid identification of phosphopeptid...