Primary resistanceSPP1-CD44 signalingCell–cell communicationMAPK signalingImmune checkpoint inhibitors (ICIs) are a cornerstone therapy for advanced renal cell carcinoma (RCC). However, significant rates of primary resistance hinder their efficacy, and the underlying mechanisms remain poorly understood. ...
佰傲谷: CD44是一种复杂的跨膜粘附糖蛋白,表达于人的多种细胞,包括胚胎干细胞、分化细胞和癌细胞。转录过程中不同的选择性剪接,产生CD44的两种亚型,包括标准亚型(CD44s)和CD44变异亚型(CD44v)。CD44是公认的肿瘤干细胞的标志物,是上皮细胞间充质转化(EMT)关键调节因子,参与肿瘤的发生,进展和转移。C… ...
Whereas, the inhibited proliferation and enhanced apoptosis induced by silence of SPP1 could be rescued by the activation of PKCα, which suggested that SPP1 functioned through PKCα. Moreover, both CD44 and αvβ3 were found expressed in SCs and increased after peripheral nerve injury. Silence...
Experiments on the transmission of yellow dwarf (A. virus 1) and Aster yellows (C. virus 1 A) viruses to some A. spp. by sap inoculation. 来自 CAB Direct 喜欢 0 阅读量: 13 作者: D Ksiazek 摘要: At Inst. Ecology, Polish Acad. Sci., Warsaw, onion yellow dwarf virus [map 46] ...
Single‐cell transcriptome sequencing reveals SPP1‐CD44‐mediated macrophage–tumor cell interactions drive chemoresistance in TNBCdoi:10.1111/jcmm.18525Liu, FuzhongZhang, JunfengGu, XiaoweiGuo, QiuyangGuo, WenjiaJournal of Cellular & Molecular Medicine...
Specifically, in alveolar macrophages (AMs), we observed that PPARG was significantly downregulated, while SPP1 was highly expressed. Importantly, PPARG serves as a transcriptional regulator of SPP1, which in turn mediates intercellular signaling via CD44. Based on these findings, we propose a novel...
CD44Intrahepatic cholangiocarcinomaSPP1Single-cell RNA sequencingTumor microenvironmentJournal of Cancer Research and Clinical Oncology - To demonstrate the biological function of Secreted Phosphoprotein 1(SPP1) and its immune suppressive role in the progression intrahepatic......
CD44Cancer Stem CellsCancer-Associated FibroblastOPN/SPP1Pancreatic CancerTumor-microenvironment factors and cancer stem cells (CSCs) play a critical role in the aggressiveness of pancreatic cancer (PC). However, the degree to which tumor-microenvironment factors promote stemness remains unexplored. Here...
344.1: Single-cell and spatial transcriptomics elucidate Spp1/Cd44-mediated tubular damage and neutrophil migration in acute kidney injury.doi:10.1097/01.tp.0001065680.44560.a5Wang, JiayuZheng, XinHu, XiaopengLippincott Williams & WilkinsTransplantation...
It was shown that four, four, and two single nucleotide polymorphisms (SNP) loci were detected for the ABCG2, CD44, and SPP1 genes, respectively, and the different genotypes of these 10 SNPs significantly affected the milk production performance of Chinese Holstein cattle in terms of milk ...