47, focusing on liver cancer and colorectal cancer respectively, demonstrated that FAP + fibroblast and SPP1 + macrophage contribute to ECM remodeling and orchestrate the formation of a connective tissue hyperplasia microenvironment, thereby impeding lymphocyte infiltration into tumor cores and ...
(1,2). SPP1 binds to cells through integrin and non-integrin receptors, as well as the adhesion receptor CD44 in an RGD-independent manner, enabling SPP1 to induce a number of functional effects including macrophage chemotaxis, cytoprotection, and regulation of T helper type 1 cells (2). ...
为了研究巨噬细胞通过常见的L–R对(TNFSF12–TNFRSF12A和SPP1–CD44)对肿瘤细胞的特异性影响,我们进一步计算了癌症细胞中TNFRSF12 A或CD44表达与标志性特征评分之间的相关性。结果显示,血管生成、糖酵解和EMT是与CD44表达最相关的生物学过程,而在癌症细胞中,通过NFκB、血管生成、IL6_JAK_STAT3途径和EMT的TNFα...
Alveolar macrophagePPARGSPP1CD44Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease. It is characterized by inflammation and fibrosis in the lung parenchyma and interstitium. Given its poor prognosis and limited treatment options, understanding the underlying molecular ...
47, focusing on liver cancer and colorectal cancer respectively, demonstrated that FAP + fibroblast and SPP1 + macrophage contribute to ECM remodeling and orchestrate the formation of a connective tissue hyperplasia microenvironment, thereby impeding lymphocyte infiltration into tumor cores and ...
分泌型磷蛋白-1(SPP1),也称为骨桥 蛋白(OPN),是由人染色体 4q22.1 上编码的 SPPL 基因 分泌的蛋白质,其与许多粘附受体结合基序相互作用, 包括 C 端 CD44v6 结构域和凝血酶切割的 N 端整联蛋 白结构域[17].最近的研究表明 SPP1 是一种与肿瘤密切 相关的细胞外基质蛋白,参与调节肿瘤细胞的侵袭,迁移,...
为了研究巨噬细胞通过常见的L–R对(TNFSF12–TNFRSF12A和SPP1–CD44)对肿瘤细胞的特异性影响,我们进一步计算了癌症细胞中TNFRSF12 A或CD44表达与标志性特征评分之间的相关性。结果显示,血管生成、糖酵解和EMT是与CD44表达最相关的生物学过程,而在癌症细胞中,通过NFκB、血管生成、IL6_JAK_STAT3途径和EMT的TNFα...
2024年2月,广西医科大学附属肿瘤医院的向邦德教授团队发表一篇题为“Integrating single‑cell and bulk RNA sequencing reveals CK19 + cancer stem cells and their specific SPP1 + tumor‑associated macrophage niche in HBV‑related hepatocellular carcinoma”的研究成果。本研究通过整合单细胞和Bulk RNA测序数...
为了研究巨噬细胞通过常见的L–R对(TNFSF12–TNFRSF12A和SPP1–CD44)对肿瘤细胞的特异性影响,我们进一步计算了癌症细胞中TNFRSF12 A或CD44表达与标志性特征评分之间的相关性。结果显示,血管生成、糖酵解和EMT是与CD44表达最相关的生物学过程,而在癌症细胞中,通过NFκB、血管生成、IL6_JAK_STAT3途径和EMT的TNFα...
adenocarcinoma;GM-CSF;lung;macrophage;SPP1 1. Introduction Lung cancer is the most common cause of cancer death in the Japanese population, and its incidence increases sharply after the age of 50 years [1,2]. Although recent advancements and the widespread use of computed tomography scanning cont...