他们的最新研究“CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers”已于著名期刊《Science》上发表。作者发现,由 CXCL9 和 SPP1 这两个基因的表达所定义的巨噬细胞极性的变化是肿瘤微环境的一个简单而关键的特征。CXCL9:SPP1的比例可以描述癌症中抗肿瘤免疫细...
SPP1 is associated with NPC progression and worse patient outcomes.NPC-derived SPP1 promotes M2 polarization via CD44/JAK2/STAT3 signaling.SPP1-driven M2 macrophage signature correlates with potential immunotherapy response.doi:10.1016/j.intimp.2024.113944Zongwei Huang...
et al. SPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration. Br J Cancer 130, 1770–1782 (2024). https://doi.org/10.1038/s41416-024-02683-x Download citation Received03 December 2023 Revised29 March 2024 ...
研究发表在《Science》上，文章标题为：“CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers”。研究人员利用患者间差异，研究肿瘤微环境如何影响头颈部鳞状细胞癌的进展。作者发现，由两个基因CXCL9和SPP1的表达决定的巨噬细胞极性的变化是肿瘤微环境的一个简单但关...
[1] Wei J , Chen Z , Hu M ,et al.Characterizing Intercellular Communication of Pan-Cancer Reveals SPP1+ Tumor-Associated Macrophage Expanded in Hypoxia and Promoting Cancer Malignancy Through Single-Cell RNA-Seq Data[J].Frontiers in cell and developmental biology, 2021, 9:749210.DOI:10.3389/...
[1] Wei J , Chen Z , Hu M ,et al.Characterizing Intercellular Communication of Pan-Cancer Reveals SPP1+ Tumor-Associated Macrophage Expanded in Hypoxia and Promoting Cancer Malignancy Through Single-Cell RNA-Seq Data[J].Frontiers in cell and developmental biology, 2021, 9:749210.DOI:10.3389/...
摘要 目的探讨分泌性磷蛋白1(SPP1)及程序性死亡因子配体-1(PD-L1)在肝细胞癌(HCC)患者中的表达及与M2巨噬细胞的相关性以及对预后的影响。方法采用免疫组化法检测81例肝癌患者中SPP1、PD-L1以及CD163(...展开更多 Objective To evaluate the expression of programmed death receptor ligand-1(SPP1),programmed...
近期,来自瑞士University of Geneva的Mikael J. Pittet研究组在Science上发表题为CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers的文章,将病人个体差异这一变量加入RNA测序数据处理和分析之中,并进一...
Metabolic reprogramming affects macrophage polarization and function by metabolites, such as lactate [61, 62]. The utility of lactate induces M2 polarization of TAMs, which in turn promotes the aggressive phenotype of glioma cells [63]. In inflammatory diseases, VSIG4 activates the PI3K/Akt-STAT3...
2023年8月4日,瑞士日内瓦大学领导的国际研究团队在Science(IF=56.9)发表了研究论文:CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers。由 CXCL9 和 SPP1 这两个基因的表达所定义的巨噬细胞极性的变化是肿瘤微环境的一个简单而关键的特征。CXCL9:SPP1的比例可...