Macrophage diversity in cancer revisited in the era of single-cell omics. Trends Immunol. 2022;43(7):546–63. Article CAS PubMed Google Scholar Hoeft K. et al. Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner. Cell Reports. 2023;...
1) Macrophage Regulation in IDD: SPP1 activates the PERK/ATF4/IL-10 signaling axis in macrophages, increasing IL-10 production, essential for inhibiting msi-IDD progression. 2) Effective Intervention: Inhibition of SPP1 in macrophages shows potential for therapeutic intervention, significantly mitigating...
Fig. 1: Single-cell Atlas of paired human normal mucosa and CRC tissues. aGraphic overview of this study design. Normal mucosa and tumor tissue from CRC patients were processed into single-cell suspension and unsorted cells were used for scRNA-seq with 10x Genomics. Tumor slides were processed...
Functionally, knocking down SPP1 expression in vitro inhibited the secretion of fibrosisrelated factors and M2 polarization in macrophages. Furthermore, knocking down SPP1 expression inhibited the macrophageinduced epithelialtomesenchymal transition in both epithelial and fibroblastic cells. ...
Microbial DNA enrichment promotes liver steatosis and fibrosis in the course of non-alcoholic steatohepatitis. Acta Physiol (Oxf), 2022;235(3):e13827. Li J, Diao B, Guo S, Huang X, Yang C, Feng Z, Yan W, Ning Q, Zheng L, Chen Y, Wu Y. VSIG4 inhibits proinflammatory macrophage ...
The involvement of SPP1 protein in fibrosis was studied further. Knocking down the expression of SPP1 in exosomes resulted in a decrease in fibrosis-related indicators. These results help to understand that exosomal protein can mediate cell communication and play a key role in the transition from...
V-set and immunoglobulin domain-containing 4 (VSIG4) positive tumor-associated macrophage (VSIG4+ TAM) is an immunosuppressive subpopulation newly identified in aggressive cancers. However, the mechanism how VSIG4+ TAMs mediate immune evasion in aggressi
Macrophage infiltration plays a central role in AS and was previously thought to be a late consequence of steatosis. However, recent studies have shown that the activation and infiltration of macrophages are also early initiating event in NASH. Inhibition of macrophage infiltration has been shown to...
Macrophage infiltration plays a central role in AS and was previously thought to be a late consequence of steatosis. However, recent studies have shown that the activation and infiltration of macrophages are also early initiating event in NASH. Inhibition of macrophage infiltration has been shown to...
Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage. Lab Invest 2013; 93: 434–449. 38 Arriazu E, Ge X, Leung TM, Magdaleno F, Lopategi A, Lu Y et al. Signalling via the ...