47, focusing on liver cancer and colorectal cancer respectively, demonstrated that FAP + fibroblast and SPP1 + macrophage contribute to ECM remodeling and orchestrate the formation of a connective tissue hyperplasia microenvironment, thereby impeding lymphocyte infiltration into tumor cores and ...
47, focusing on liver cancer and colorectal cancer respectively, demonstrated that FAP + fibroblast and SPP1 + macrophage contribute to ECM remodeling and orchestrate the formation of a connective tissue hyperplasia microenvironment, thereby impeding lymphocyte infiltration into tumor cores and ...
The differences in infiltrated cell types between tumor-adjacent tissues and tumor tissues suggest that a dynamic remodeling of TME plays an important role in CRC progression (Supplementary Note2). MSCs and fibroblast-like cells have long been suggested as a key stromal cell type involved in regula...
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease characterized by a heterogeneous tumor immune microenvironment (TIME). Tumor-associated macrophages (TAMs) constitute the major innate immune population in the TIME where they fac
Furthermore, knocking down SPP1 expression inhibited the macrophageinduced epithelialtomesenchymal transition in both epithelial and fibroblastic cells. Treatment with SPP1 inhibitors in vivo enhanced lung function and ameliorated pulmonary fibrosis. Mechanistically, SPP1 appears to promot...
SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation 来自 国家科技图书文献中心 喜欢 0 阅读量: 49 作者:Ruoxuan Huang,Changfu Hao,Di Wang,Qiuyan Zhao,Chao Li,Chen Wang,Wu Yao 摘要: The occurrence and development of silicosis is related to the interaction of ...
31 Similarly, LGALS3 promotes inflammation by stimulating macrophage activation and migration and LGALS3 levels are associated with neutrophils accumulation in patients with chronic obstructive pulmonary disease.32 As SPP1 and LGALS3 increased plasma levels in PMF patients had never been reported before,...
V-set and immunoglobulin domain-containing 4 (VSIG4) positive tumor-associated macrophage (VSIG4+ TAM) is an immunosuppressive subpopulation newly identified in aggressive cancers. However, the mechanism how VSIG4+ TAMs mediate immune evasion in aggressive cancers have not been fully elucidated. In...
Subsequently, we established an SPP1-driven M2 macrophage signature using a machine-learning-based framework to predict patient prognosis. The results of our analysis indicated that SPP1 is associated with an elevated risk of disease progression and poor prognosis in NPC. Single-cell analysis ...
V-set and immunoglobulin domain-containing 4 (VSIG4) positive tumor-associated macrophage (VSIG4+ TAM) is an immunosuppressive subpopulation newly identified in aggressive cancers. However, the mechanism how VSIG4+ TAMs mediate immune evasion in aggressi