Plant mitochondrial genomes can be complex owing to highly recombinant structures, lack of gene syntenies, heavy RNA editing and invasion of chloroplast, nuclear or even foreign DNA by horizontal gene transfer (HGT). Leptosporangiate ferns remained the last major plant clade without an assembled mi...
R47HKI rats. The artifactual splicing seen in KI mouse models is not present; additionally, two novel isoforms of ratTrem2are described.Trem2R47Hrat brains have lower human Aβ38, sAPPα and sAPPβ levels. Thus,Trem2R47HKI rats may prove valuable to define pathogenic mechanisms triggered by...
Comprehensive proteomic analysis of the human spliceosome The precise excision of introns from pre-messenger RNA is performed by the spliceosome, a macromolecular machine containing five small nuclear RNAs and num... Z Zhou,LJ Licklider,SP Gygi,... - 《Nature》 被引量: 2846发表: 2002年 Female...
This protein is implicated in the regulation of alternative splicing in neurons and muscles [37] and has been shown as important for the survival of human embryonic stem cells [38]. According to our results, during embryogenesis, the expression levels of the isoforms in embryos nearly double ...
Regulation of alternative splicing of a partially deleted gene of human type II procollagen in transgenic miceTransfer of gene into the early embryo forms the basis of a powerful tool to impart new and useful characteristics into existing breeds of animals (1). Recombinant DNA techniques have made...
In light of that, the most effective strategies for identifying tumor-promoting oncofetal splice variants and mechanisms can come out of integrating data from human HCC cell-based models64,65 and tissue specimens66 with the most appropriate animal models.67, 68, 69 Up-regulation of the Onco...
Our work reveals that deletion of STRAP has effects mainly on exon skipping during the lineage commitment, which is distinct from the recently elucidated AS programs during the neural differentiation of human iPSCs, in which increased intron retention is a predominant feature of AS at early stage55...
Human primers specific for the genes LEP, HBB, PAX3, ESR2, TPH1, ABCA4 and ATP2A2 were used to identify clones in a canine BAC library. Subcloning of the p... JC Dickin,TD Thue,FC Buchanan - 《Animal Genetics》 被引量: 53发表: 2004年 加载更多来源...
(Dobin et al. 2013) was used to align each read uniquely to the Hg19 human genome (default parameters except alignSJoverhangMin 8, alignSJDBoverhangMin 3, outFilterMismatchNmax 999, alignIntronMin 20, alignIntronMax 1000000, alignMatesGapMax 1000000, outFilterMismatchNoverReadLmax 0.1). To ...
118 glioma tissue samples were randomly selected. These patients were 74 men and 44 women who underwent surgery between 1999 and 2013. The mean age of the patients at the time of diagnosis was 46.9 years, ranging from 9 to 80 years. The use of human samples was approved by the Ethics Co...