The prevalence of unproductive splicing, along with the observation that unproductive splicing anti-correlates with gene expression levels genomewide, predicts that genetic effects on RNA splicing would often impact RNA expression levels. To test this prediction, we used quantitative trait loci (QTL) ma...
Of course, as admirable as it is that the UK is considering the most ethical ways of handling ACHM, I think there's little chance they'd be able to stop the most "heinous" forms of human-animal hybridization from occurring. As the Academy points out in their report, splicing human gen...
Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm. Genome 10, 983–986 (1999). CAS PubMed Google Scholar Flanagan, J. G., Chan, D. C. & Leder, P. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and...
aStrong correlation of gene expression between resting human (x) and mouse (y) blood neutrophils. Left: all genes (r = 0.84,P < 2.2e-16). Middle: transcription factors, highlighted in green (r = 0.87,P < 2.2e-16). Transcription factors were retrieved from a curated ...
Identification and sequencing of different sized SPEC1 cDNA clones revealed that the transcript size heterogeneity was due to alternative splicing in the 3'-untranslated region. In addition, a distinct SPEC1 splice variant from within the coding sequence, SPEC1-[beta], was identified and detected ...
combines study of genetic, environmental and clinical diagnostic testing, including biomarkers, to individualized patient care. In this perspective, we used subgroups of specific ALS-linked gene mutations to go through existing animal models and to provide a comprehensive profile of the differences and ...
Numerous different gene mutations have been found in familial cases of ALS, such as mutations in superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43), fused in sarcoma (FUS), C9ORF72, ubiquilin-2 (UBQLN2), optineurin (OPTN) and others. Multiple animal models were ...
We present two Web interfaces that generate genetic maps for given sets of human or mouse microsatellite markers. The genetic maps are generated from available databases using linear interpolation of physical map distances to infer genetic map positions for missing markers in these databases.关键词:HU...
Cattle is one of the most economically important livestock species, supplying humans with a substantial fraction of animal protein. Driven by the high selection intensity of economically important traits, compared to humans, cattle has a different population structure, such as smaller effective population...
Many gene expression quantitative trait locus (eQTL) studies have published their summary statistics, which can be used to gain insight into complex human traits by downstream analyses, such as fine mapping and co-localization. However, technical differe