Analysis of RNA samples from different embryonic tissues suggested that alternative splicing might be confined to tissue destined to become bone. 20 refs., 2 figs. 展开 关键词: Animals Humans Mice Collagen Cloning, Molecular Sequence Alignment Sequence Homology, Amino Acid Species Specificity RNA ...
The Vasa genes in humans and mice are regulated by the methylation state of tissue-specific differentially methylated regions (TDMRs). The methylation status of the CpG islands region in the promoter is related to the specific expression of Vasa and spermatogenesis, in which the Vasa promoter is...
(4) Conserved noncoding sequences are found primarily in or near the 5′-UTR or the first intron of genes, and seldom in the intergenic regions. Many of these conserved blocks are likely to be -regulatory elements. 展开 关键词: Animals Humans Mice Proteins RNA, Untranslated Sequence Analysis...
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Mutations in CatSper1 and 2 are associated with male infertility in humans9–11. In addition to the pore-forming proteins, the sperm Ca2 + channel contains the auxiliary subunits, CATSPERβ and CATSPERγ12,13. High amplitude and highly curved movements of the tail char- acterize ...
Taken together, these results posit that although chronic stress may induce depressive behavior, its molecular underpinnings differ from those of endogenous depression in animals and possibly in humans, suggesting the need for different treatments. The identification of novel endogenous depression-related ...
Sxl autoregulates the splicing of its own pre-mRNA and activates transformer (tra) by regulating splicing of the pre-mRNA of tra. The products of the tra and the transformer-2 (tra-2) genes then regulate the splicing of the pre-mRNA of the doublesex (dsx) gene, leading to the ...
This approach, however, has a high chance of failure, even when the selected biomarkers are mutually expressed in humans and animals alike. Because the gene regulation mechanism involves a complex network interaction between genes, the fact that humans and animals share a mutual gene does not ...
Not only the location but also the DNA sequence of each locus are unique and distinctive compared to those of other loci. The key rationale of using the mutant mouse as a model for human disease is the high similarity of the entire genome between humans and mice. Classically, the size of...
Identifying the genetic determinants of emotionality in humans; insights from rodents. Neurosci. Biobehav. Rev. 31, 115–124 (2007). Article CAS PubMed Google Scholar Morris, J. S. et al. A differential neural response in the human amygdala to fearful and happy facial expressions. Nature ...