databaseRNA target motifssplicing factor expressionmutation effectSplicing is the most frequently altered biological process by mutations within gene regions. Information for splicing is recognized by several factors that bind pre-mRNA sequence and, through coordinated interaction, yield mature transcripts. ...
Source Data Extended Data Fig. 9 Source Data Extended Data Fig. 10 Rights and permissions Reprints and permissions About this article Cite this article Jayavelu, A.K., Schnöder, T.M., Perner, F. et al. Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms. Nature 588, ...
In the case of serine/arginine-rich splicing factor 2 (SRSF2), impaired differentiation has been linked to a specific splicing change in a downstream gene (enhancer of zeste homologue 2 (EZH2)). Spliceosomal mutations may affect cellular processes, including epigenetic regulation, the DNA damage ...
U2 snRNP auxiliary factor (U2AF) is an essential heterodimeric splicing factor composed of two subunits, U2AF65 and U2AF35. During the past few years, a number of proteins related to both U2AF65 and U2AF35 have been discovered. Here, we review the conserved structural features that ...
Here we report that the splicing factor RBM4 suppresses proliferation and migration of various cancer cells by specifically controlling cancer-related splicing. Particularly, RBM4 regulates Bcl-x splicing to induce apoptosis, and coexpression of Bcl-xL partially reverses the RBM4-mediated tumor ...
Four of these proteins have been identified as hnRNP C, PTB (polypyrimidine-binding protein), and the splicing factors U2AF (U2 auxiliary factor) and PSF (PTB associated splicing factor). We have mapped their binding sites to two specific sequences 3′ of the CUG tract. Careful examination ...
We can see a direct correlation between expression of Fox2, a known splicing factor, and the alternative splicing of cassette exons containing binding sites for this protein in the neighbouring introns. Thus, our results suggest that the effects of alternative mRNA isoforms should now be ...
Serine and arginine rich splicing factor 1 SRSF6: Serine and arginine rich splicing factor 6 STAD: Stomach adenocarcinoma TCGA: The cancer genome atlas TGCT: Testicular germ cell tumors THCA: Thyroid carcinoma THYM: Thymoma UCEC: Uterine corpus endometrial carcinoma UCS: Uterine carcinosa...
HuR/TIA1 is involved in alternative splicing regulation of SIRT1 Pre-mRNA by promoting or inhibiting exon8 exclusion [33]. TIA1, which functions as an ARE-binding regulatory factor, is involved in cyclooxygenase-2 translational regulation by binding the AU-rich element (ARE) within the COX-2...
The splicing factor ESRP1 regulates CD44 splice switching during the epithelial-mesenchymal transition15, and SF3B2 drives prostate cancer progression through AS of androgen receptor (AR) to increase AR-V7 expression16. Conversely, RBM4 is downregulated in cancer tissues, and this suppresses tumor ...