A humanized NOVA1 splicing factor alters mouse vocal communications The neuron-specific RNA binding protein NOVA1 has a single amino acid substitution unique to modern humans. Here, the authors characterize the evolutional specificity and the function of the substitution. Studies using humanized NOVA1 ...
To expand the molecular determinants for cancer classification, herein we have analyzed differentially regulated AS events in molecular subtypes of cancer using TCGA data. To promote the discovery of AS events as biomarkers, we have developed a pan-cancer database named AS-CMC (Alternative Splicing ...
Alternative splicingSRSF1Myocardial infarctionApoptosisBcl2L12Aberrant alternative splicing (AS) events, triggered by the alterations in serine/arginine splicing factor 1 (SRSF1), a member of the SR protein family, have been implicated in various pathological processes. However, the function and ...
The Alternative Splicing Mutation Database (ASMD) presents a collection of all known mutations inside human exons which affect splicing enhancers and silencers and cause changes in the alternative splicing pattern of the corresponding genes. Findings An algorithm was developed to derive a Splicing Potent...
Woolard J, Nowak D, Ladomery M, Harper SJ, Bates DO: Splice fac- tor regulation of alternative splicing of VEGFisoform fami- lies [abstract]. FASEB Journal 2006, 20:A539.SJ, Bates DO: Splice factor regulation of alternative splicing of VEGFisoform families [abstract - Woolard, Nowak, et...
RT-PCR analysis of the two other candidates only gave rise to a single PCR product for all samples tested (data not shown). Alternative Splicing in Normal Versus Cancer Samples— Tumor-specific alternative splicing events were identified by exon array analysis of normal and tumor tissue samples ...
A large number of splicing proteins associated with SNAIL, including SRSF1, a regulator of alternative splicing. Co-immunofluorescence and co-immunoprecipitation data from our lab indicate that SNAIL associates with splicing protein SRSF1. Further, SNAIL co-immunoprecipitated with SRSF1 in the presence...
Alternative splicingSplice site predictionGC contentOligonucleotide-frequency modelsNeural networksASSPHuman alternative isoform, cryptic, skipped, and constitutive splice sites from the ALTEXTRON database were analysed regarding splice site strength, composition, GC content, position and binding site strength ...
Alternative splicing is known to increase the complexity of mammalian transcriptomes since nearly all mammalian genes express multiple pre-mRNA isoforms. However, our knowledge of the extent and function of alternative splicing in early embryonic develop
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