Alternative splicing affects more than 95% of multi-exon genes in the human genome. These changes affect the proteome in a myriad of ways. Here, we review our understanding of the breadth of these changes from their effect on protein structure to their influence on interactions. These changes ...
Function of alternative splicing[J] . Stefan Stamm,Shani Ben-Ari,Ilona Rafalska,Yesheng Tang,Zhaiyi Zhang,Debra Toiber,T.A. Thanaraj,Hermona Soreq.Gene . 2004Stefan Stamm,Shani Ben-Ari,Dona Rafalska,et al.Function of alternative splicing. Gene . 2005...
Alternative splicing (AS) of mRNA precursors as a common mechanism regulating gene expression can increase the diversity of the transcriptome and expand the information content1. In many cases, each mRNA transcript encodes a unique polypeptide with a certain biological function. In other cases, some ...
Alternative splicing is one of the most important mechanisms to generate a large number of mRNA and protein isoforms from the surprisingly low number of human genes. Unlike promoter activity, which primarily regulates the amount of transcripts, alternative splicing changes the structure of transcripts ...
We also determine the effect of PEX26 deficiency on PEX5 and PEX1 steady-state levels and map the PEX6-binding domain in PEX26. Additionally, we describe extensive alternative splicing of PEX26 in fibroblasts and various human tissues that creates a cytoplasmic, but nevertheless functional, PEX...
Tran- scription of this provirus by the cellular RNA polymerase II generates a polycistronic pre-mRNA that contains at least four 5' splice sites (5'ss) D1-4 and eight 3' splice sites (3'ss) A1, 2, 3, 4c, 4a, 4b, 5 and 7 that enable alternative splicing of more than 40 ...
Almost all of the genes in cluster 78 have been implicated in alternative splicing, e.g. recent studies of KHDRBS1, aka Sam68[31]. By contrast, the large majority of the other splicing factors are not part of significant clusters. This suggests the existence of specifically-regulated ...
(green for PKR and yellow for PKL). PKM encodes PKM1 and PKM2 subtypes by alternative splicing of mutually exclusive exon 9 and 10, and a high expression level of PTB, hnRNP 1 & hnRNP A1/A2 are required for during the cleavage process of exon 9 of PKM2, while the cleavage process of...
Alternative splicing is an essential molecular mechanism that increase the protein diversity of a species to regulate important biological processes. Ecdysone receptor (EcR), an essential nuclear receptor, is essential in the molting, growth, development
Alternative splicing of OsLG3b controls grain length and yield in japonica rice. Plant Biotechnol. J. 16, 1667–1678 (2018). CAS PubMed PubMed Central Google Scholar Sun, L. et al. GS6, a member of the GRAS gene family, negatively regulates grain size in rice. J. Integr. Plant ...