Heslinga MJ, Willis GM, SobcZynski DJ, Thompson AJ, Eniola-Adefeso O. One-step fabrication of agent-loaded biodegradable microspheroids for drug delivery and imaging applications. Colloids Surf B Biointerfaces 2014, 116:55-62.Heslinga MJ, Willis GM, Sobczynski DJ, Thompson AJ, Eniola-...
Human kidney-on-a-chip models will also be discussed, while exploring the advantages and potential limitations of this rapidly emerging field for the study of human kidney disease and drug testing.Similar content being viewed by others Organs-on-chip technology: a tool to tackle genetic kidney ...
Microencapsulated multicellular tumor spheroids as a tool to test novel anticancer nanosized drug delivery systems in vitro. Privalova AM,Uglanova SV,Kuznetsova NR,et al. Journal of Nanoscience and Nanotechnology . 2015PRIVALOVA, A.M.; UGLANOVA, S.V.; KUZNETSOVA, N.R.; KLYACHKO, N.L.; ...
Cellulose‐based hydrogels are promising sustainable materials for a variety of applications, including tissue engineering, water treatment, and drug delivery. However, the tailoring of diverse properties by efficient green chemistry methods is an ongoing challenge. Here, composite hydrogels of consistent ...
transplantation procedure because the increased cell-to-cell interaction in spheroids enhances cell survival and its functions after the transplantation into the... T Endo,K Itaka,M Shioyama,... - 《Drug Delivery & Translational Research》 被引量: 3发表: 2012年 Gene transfection to spheroid cultu...
Cancer cell spheroids for screening of chemotherapeutics and drug-delivery systems Over the last few decades, the most popular platform to perform high-throughput screening for viable anti-neoplastic compounds has been monolayer cell cult... NU Centerforpharmaceuticalbiotechnologyandnanomedicine,I Nemucore...
These gradients are also found in many solid tumors due to poor vascularization and can influence cell state, drug delivery and therapy efficacy6. The inhomogeneous distribution of nutrients, gas and cellular waste, caused by the limited molecular diffusion between the MCTS surface and center, ...
First, we demonstrated that both BKM120 and dabrafenib did not affect the ability of BBB spheroids to restrict the entry of high molecular weight dextran (Fig. 5a), suggesting that the integrity of the spheroid's surface barrier remained intact in the presence either drug for 24 h at 10 mM...
Our study revealed that establishment of tumors by transplantation of spheroids significantly improved subcutaneous xenograft model of PDAC, which stays the most widely used animal model for testing of new drugs and drug delivery approaches. Spheroid based tumors abundantly produced different extracellular ...
platforms in detriment of non-biomimetic 2D tissue-culture plastics [2]. The effects of these 3D culture systems have shown to impact cell behavior at various levels ultimately affecting drug sensitivity through changes observed in cell morphology, cell viability and cell survival pathways among ...