Speckle-type POZ protein(SPOP), a substrate adaptor of Cul3 ubiquitin ligase, plays crucial roles in solid neoplasms by promoting the ubiquitination and degradation of substrates. Limited studies have shown that SPOP is overexpressed in human renal cell carcinoma (RCC) tissue. However, the exact ...
The speckle-type POZ protein (SPOP) was first cloned as a novel antigen from a scleroderma patient in 1997 [16], and was identified as an E3 ubiquitin-protein ligase that mediates ubiquitination and degradation of targeted proteins through proteasomal pathways [17,18,19]. Cancer genome characteri...
Speckle-Type POZ Protein Human Recombinant 英文名称: Speckle-Type POZ Protein Human Recombinant 总访问: 269 国产/进口: 进口 半年访问: 24 产地/品牌: prospec 产品类别: 细胞生物学试剂 规格: PRO-195 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 询价 立即询价 电话咨询 ...
Abstract Speckle-type POZ protein (SPOP) is an adaptor of the cullin 3-based ubiquitin ligase responsible for the degradation of oncoproteins frequently overexpressed in many tumor cells. Altered expression and somatic mutations of SPOP have been observed in various tumor types with chromosomal aberrati...
However, although the important role of ELK3 in tumor progression is well-known, the molecular mechanisms involved in the regulation of ELK3 protein degradation through ubiquitination remain largely unknown. Speckle-type POZ protein (SPOP) is an adaptor protein of Cullin3 (CUL3)-based ubiquitin ...
Stabilization of Speckle-type POZ Protein (Spop) by Daz Interacting Protein 1 (Dzip1) Is Essential for Gli Turnover and the Proper Output of Hedgehog Signaling.Stabilization of Speckle-type POZ Protein (Spop) by Daz Interacting Protein 1 (Dzip1) Is Essential for Gli Turnover and the Proper ...
Speckle-type POZ protein (SPOP); c-jun N-terminal kinase (MAPK8; JNK)Studies in human cell culture and in tissue samples suggest that SPOP is a biomarker and a potential target for treating clear cell RCC.doi:10.1038/scibx.2009.400None...
The speckle-type POZ adaptor protein (SPOP) is part of the ubiquitin ligase E3 cullin-3 RING-box1 complex, responsible for the ubiquitination and proteasomal degradation of biomolecules involved in cell cycle control, proliferation, response to DNA damage, epigenetic control, and hormone signaling, ...
Identification of speckle-type POZ protein somatic mutations in African American prostate cancer 体细胞突变前列腺癌POZ蛋白肿瘤抑制基因前列腺肿瘤鉴别非洲点缀类型 POZ 蛋白质(SPOP ) 是在前列腺癌症(PCa ) 的肿瘤 suppressor.SPOP 体的变化在欧洲降下的那些的多达 15% PCa 被报导了.然而,在非洲的美国人(AA ...
Speckle-type POZ protein mutations interrupt tumor suppressor function of speckle-type POZ protein in prostate cancer by affecting androgen receptor degradation 雄激素受体基因突变前列腺癌POZ抑制功能蛋白降解斑点定序研究的大规模 exome 揭示了染色体的区域,它贡献这学习的抵抗前列腺癌症(CRPC ) phenotype.1,2...