Identification of speckle-type POZ protein somatic mutations in African American prostate cancer 体细胞突变前列腺癌POZ蛋白肿瘤抑制基因前列腺肿瘤鉴别非洲点缀类型 POZ 蛋白质(SPOP ) 是在前列腺癌症(PCa ) 的肿瘤 suppressor.SPOP 体的变化在欧洲降下的那些的多达 15% PCa 被报导了.然而,在非洲的美国人(AA ...
speckle-type POZ protein (SPOP), regulates TWIST1 in breast cancer remains unknown. In this study, we report that SPOP physically interacts with, ubiquitinates, and destabilizes TWIST1. SPOP promotes K63-and K48-linked ubiquitination
Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor that is frequently mutated in human cancers. Our previous findings have indicated that SPOP is mutated and functions as a novel tumor suppressor in hepatoblastoma (HB). However, the biological roles and clinical significance of ...
Abstract Speckle-type POZ protein (SPOP) is an adaptor of the cullin 3-based ubiquitin ligase responsible for the degradation of oncoproteins frequently overexpressed in many tumor cells. Altered expression and somatic mutations of SPOP have been observed in various tumor types with chromosomal aberrati...
However, although the important role of ELK3 in tumor progression is well-known, the molecular mechanisms involved in the regulation of ELK3 protein degradation through ubiquitination remain largely unknown. Speckle-type POZ protein (SPOP) is an adaptor protein of Cullin3 (CUL3)-based ubiquitin ...
Speckle-Type POZ Protein Human Recombinant 英文名称: Speckle-Type POZ Protein Human Recombinant 总访问: 269 国产/进口: 进口 半年访问: 24 产地/品牌: prospec 产品类别: 细胞生物学试剂 规格: PRO-195 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 询价 立即询价 电话咨询 ...
Stabilization of Speckle-type POZ Protein (Spop) by Daz Interacting Protein 1 (Dzip1) Is Essential for Gli Turnover and the Proper Output of Hedgehog Signaling.Stabilization of Speckle-type POZ Protein (Spop) by Daz Interacting Protein 1 (Dzip1) Is Essential for Gli Turnover and the Proper ...
Speckle-type POZ protein (SPOP); c-jun N-terminal kinase (MAPK8; JNK)Studies in human cell culture and in tissue samples suggest that SPOP is a biomarker and a potential target for treating clear cell RCC.doi:10.1038/scibx.2009.400None...
Here, we report that Dzip1 regulates Gli/Ci turnover by preventing degradation of speckle-type POZ protein (Spop), a protein that promotes proteasome-dependent turnover of Gli proteins. We provide evidence that Dzip1 regulates the stability of Spop independent of its function in ciliogenesis. ...
Speckle-type POZ proteinMatrix metalloproteinase 2Signaling pathwayElevated expression of matrix metalloproteinases (MMPs) is correlated with invasion and metastasis of colorectal cancer (CRC). Recently, a previous study has suggested that speckle-type POZ protein (SPOP) could inhibit cancer cell ...