Maternal immune activation and autism spectrum disorder: from rodents to nonhuman and human primates. Biol Psychiatry. 2017;81(5):391-401. doi:10.1016/j.biopsych.2016.10.020 PubMedGoogle ScholarCrossref 8. Meyer U. Prenatal poly(i:C) exposure and other developmental immune ...
Transient interactions in which binding partners retain substantial conformational disorder play an essential role in regulating biological networks, challenging the expectation that specificity demands structurally defined and unambiguous molecular interactions. The monoclonal antibody 6D8 recognises a completely co...
Systemic lupus erythematosus (SLE), a systemic disorder associated with autoantibody responses to nuclear and/or cytoplasmic antigens that can lead to multiorgan dysfunction, is one inflammatory disease in which several epigenomic studies have been performed. As with other inflammatory diseases, genetic ...
We showcase the potential pharmaceutical applications of the small bowel and its disorder clusters, illustrated by the known drug targets NR1I3 and NFACT1, and their small bowel-specific regulatory modules. In conclusion, disrupted long-range gene regulations in both brain and non-brain tissues ...
Association between preeclampsia and autism spectrum disorder: a population-based study. J Child Psychol Psychiatry. 2020;61(2):131–9. Article PubMed Google Scholar Mor G, Cardenas I, Abrahams V, Guller S. Inflammation and pregnancy: the role of the immune system at the implantation site. ...
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Golier JA, Schmeidler J, Legge J, Yehuda R: Twenty-four Hour Plasma Cortisol and Adrenocorticotropic Hormone in Gulf War Veterans: Relationships to Posttraumatic Stress Disorder and Health Symptoms. Biol Psychiatry. 2007, 62 (10): 1175-1178. 10.1016/j.biopsych.2007.04.027. Article CAS PubMed...
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such as chronic stress leading to dysregulated hypothalamic-pituitary-adrenal axis function, immune dysfunction, chronic inflammation,25-28 lifestyle factors (eg, alcohol and substance use), the underrecognition of hypochondriasis as a genuine psychiatric disorder that requires treatment, and/or limited ...
This deficiency leads to a progressive multi-system lysosomal storage disorder that includes coarsened facial features, large tongue, large liver and spleen, respiratory problems, heart problems, joint stifffiess and bone disease. The disease leads to death in patients usually in their first or ...