Men and women often experience different symptoms or rates of occurrence for a variety of mood disorders. Many of the symptoms of mood disorders overlap with autoimmune disorders, which also have a higher prevalence in women. There is a growing interest in exploring the immune system to provide ...
Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses. Transl Psychiatry. 2019;9:233–13. Hart BAT, den Dunnen WF. Commentary on special issue: CNS diseases and the immune system. J Neuroimmune Pharm. 2013...
Samples of blood and its various components, bone marrow, urine, or other body fluids may be required for clinical laboratory tests as aids to the examination and evaluation of the hemic system. As for any other biologic investigation, the first prerequisite in the evaluation of the hemic system...
The first is thermoregulatory disorders, which are disorders of the autonomic nervous system that impair the pathways involved in thermoregulation. Whereas these disorders sometimes present with symptoms related to heat or cold stress, more often the thermoregulatory deficit is incidental to symptoms and ...
Complement is an important component of the innate immune response with the capacity to recognize and clear infectious challenges that invade the CNS through a damaged blood brain barrier. For instance, the membrane attack complex is involved in cytotoxic and cytolytic activities while other smaller fr...
The lymphatic system is part of the circulatory and immune surveillance systems. Interstitial fluid is collected by a large network of lymph vessels that returns the excess interstitial fluid back to the heart, passing through lymph nodes that remove damaged cells and other debris.(George A.J.T....
We aim to clarify the effect of DEHP on lipid metabolism and the role of TYK2/STAT1 and autophagy. Methods In total, 160 Wistar rats were exposed to DEHP[0, 5, 50, 500 mg/(kg·d)] for 8 weeks. Lipid levels, as well as mRNA and protein levels of TYK2, STAT1, PPARγ, AOX, ...
Since the gut microbiota makes critical contributions to metabolism and maintenance of immune homeostasis and may control the central nervous system (CNS) activities through neural, endocrine, and immune pathways [9], it has been hypothesized the active role of the gut microbiota in ASD ...
S. The key role of inflammation in the pathogenesis and management of obesity and CVD. Metabolism 145, 155627 (2023). Article CAS PubMed Google Scholar Almond, M. et al. Obesity dysregulates the pulmonary antiviral immune response. Nat. Commun. 14, 6607 (2023). Article CAS PubMed Pub...
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-ass