Spatial transcriptomics (ST) has filled this gap and has been widely used in respiratory studies. This review focuses on the latest iterative technology of ST in recent years, summarizing how ST can be applied to the physiological and pathological processes of the respiratory system, with emphasis...
Transcriptomic analysis only reveals one aspect of cellular function. Spatial multi-omics is a technique that combines spatial transcriptomics with other omics modalities to reveal the multiple layers of cell function. Several methods have been developed to achieve comprehensive spatially resolved molecular ...
Its genuinely a Heisenbergian tradeoff that baffled the biologist for a long time until now; an innovative solution seems to be in place. Spatial transcriptomics (ST) is the perfect marriage between localization and quantitation without compromising either. It is a method that...
In spatial transcriptomics (ST), clustering analysis categorizes similar gene expression profiles spatially. Various AI techniques have been developed to enhance this process, utilizing machine learning (ML) and deep learning (DL) methods. Among these, methods like spatially informed clustering and predi...
论文链接:Alignment and Integration of Spatial Transcriptomics Data Abstract 空间转录组学(ST)可测量组织切片中数千个点的 mRNA 表达,同时记录每个点的 2D 坐标。(Method)本文介绍了ST实验的概率对齐(PASTE)方法,从多个临近的组织切片中对齐和整合ST数据。(Detail)PASTE 使用最优传输公式计算一对切片的一致性,该公...
今年3月 Nature子刊《Nature Methods》发表了一篇关于空间转录组学的全面综述:Museum of spatial transcriptomics,作者对1987年以来有关空间转录组学的文献进行了整理回顾,并对该领域的趋势进行了深入分析,如…
Spatial transcriptomics (ST) technologies detect mRNA expression in single cells/spots while preserving their two-dimensional (2D) spatial coordinates, allowing researchers to study the spatial distribution of the transcriptome in tissues; however, joint analysis of multiple ST slices and aligning them to...
Spatial transcriptomics (ST) measures mRNA expression across thousands of spots from a tissue slice while recording the two-dimensional (2D) coordinates of each spot. We introduce probabilistic alignment of ST experiments (PASTE), a method to align and integrate ST data from multiple adjacent tissue...
Spatial transcriptomics (ST) is a method that maps gene expression in tissue while preserving spatial information. It can reveal cellular heterogeneity, spatial organization and functional interactions in complex biological systems. ST can also complement and integrate with other omics methods to provide ...
今年3月Nature子刊《Nature Methods》发表了一篇关于空间转录组学的全面综述:Museum of spatial transcriptomics,作者对1987年以来有关空间转录组学的文献进行了整理回顾,并对该领域的趋势进行了深入分析,如实验技术的使用、研究的物种/组织和使用的计算方法等。