The SOX2OT gene is comprised of 10 exons and more than two transcription start sites. Dysregulation of SOX2OT is observed in various tumors, including lung cancer, gastric cancer, esophageal cancer, breast cancer, hepatocellular carcinoma, ovarian cancer, pancreatic ductal adenocarcinoma, laryngeal ...
We previously analyzed the role of SRY-related HMG box-2 (SOX2), a stem cell-specific transcription factor, in tumorigenesis and stemness of lung cancer cells[3, .4] Its host gene SOX2-OT is located on chromosome 3q26.33 in human, and its intron contains SOX2 that regulates the ...
SOX2 overlapping transcript (SOX2-OT) is an evolutionarily conserved long non-coding RNA (lncRNA) whose intronic region contains the transcript of pluripotency gene SRY-box transcription factor 2 (SOX2). It has been suggested that SOX2-OT can regulate its overlapping gene, SOX2. Studies demonstrate...
progression is quite intricate. MiRNA-mediated targeting strategy of lncRNAs is well documented in the mechanistic control of gene expression. SOX2OT had shown to promotes hepatocellular carcinoma development through miR-122-5p/PKM2 axis21. In non-small-cell lung cancer, SOX2OT had shown to interac...
3.3. EGFR is a target gene of miR-345-5p HBE cells treated with PM2.5, DEPs and Al2O3 NPs were harvested to extract mRNA for microarray assay. In total, 329 differentially expressed mRNAs were up-regulated more than 1.2-fold, relative to the control (Fig. 3A). These mRNA microarray ...
SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA which harbors one of the major regulators of pluripotency, SOX2 gene, in its intronic region... Alireza,Shahryari,M Saghaeian,... - 《Frontiers in Genetics》 被引量: 47发表: 2015年 Up...
Furthermore, the expression of ddx18, which may be the target gene of dre-let-7c, was up-regulated by 2.11-fold. The difference was significant (P < 0.05). It's proposed that lncRNA H19 may interact with dre-let-7c as a competitive endogenous RNA to reg...
SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA which harbors one of the major regulators of pluripotency, SOX2 gene, in its intronic region. SOX2OT gene is mapped to human chromosome 3q26.3 (Chr3q26.3) locus and is extended in a high conserved region of over 700 kb. ...
Distinct gene expression patterns of SOX2 and SOX2OT variants in different types of brain tumourslong-noncoding RNASOX2OT-S1SOX2OT-S2SOX2cancer stem cellbrain tumour.Numerous investigations have been recently published on the dysregulated expression of long-noncoding RNAs (lncRNAs) in various cancer ...
Methods Dual luciferase reporter gene assay was used to verify the targeted binding of SOX2OT to miR-34a,and miR-34a to SOX2; The SOX2OT plasmid and miR-34a were transient transfected into HCT-116 cells, and the transfection efficiency was verified...