1. Introduction 2. SOX2 in development 3. The role of SOX2 in embryonic and adult stem cells 4. The role of SOX2 in disease and cancer 5. Conclusions and future perspectives Declaration of Competing Interest ReferencesShow full outline Cited by (229) Figures (4) Tables (1) Table 1Seminar...
Recent reviews in this field have highlighted SOX2 in mammalian physiology, development and pathology. In this review, we comprehensively compile what is known to date about SOX2's involvement in cancer biology, focusing on the most recent findings in the fields of cellular signaling and cancer ...
SOX2 in development and cancer biology 2020, Seminars in Cancer Biology Show abstract The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies 2021, Frontiers in Cell and Developmental Biology Hedgehog signaling and truncated gli1 in cancer 2020, ...
SOX2 and cancer: current research and its implications in the clinic. Clin Transl Med. 2014;3:19. 7. Novak D, Hüser L, Elton JJ, Umansky V, Altevogt P, Utikal J. SOX2 in development and cancer biology. Semin Cancer Biol. 2020;67:74-82. 8. Annovazzi L, Mellai M, Caldera V,...
SOX2 in development and cancer biology. Semin Cancer Biol. 2020;67:74–82. Article CAS PubMed Google Scholar Zhang S, Xiong X, Sun Y. Functional characterization of SOX2 as an anticancer target. Signal Transduct Target Ther. 2020;5:135. Article CAS PubMed PubMed Central Google Scholar ...
J Exp Clin Cancer Res (2021) 40:372 https://doi.org/10.1186/s13046-021-02147-7 RESEARCH Open Access TMPRSS4 promotes cancer stem– like properties in prostate cancer cells through upregulation of SOX2 by SLUG and TWIST1 Yunhee Lee1†, Junghwa Yoon1,2†, Dongjoon...
https://doi.org/10.1002/cam4.3201 Novak D, Hüser L, Elton JJ, Umansky V, Altevogt P, Utikal J (2020) SOX2 in development and cancer biology. Semin Cancer Biol 67:74–82. https://doi.org/10.1016/j.semcancer.2019.08.007...
Research of the past view years expanded our understanding of the various physiological functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis, reprogramming, and cancer. However, while scientific reports featuring novel and exciting aspects of SOX2-driven biology are published...
L. The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep. 15, 642–656 (2014) . CAS PubMed PubMed Central Google Scholar Zender, L. et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125, 1253–1267 (2006)...
review, we comprehensively compile what is known to date about SOX2’s involvement in cancerbiology, focusing on the most recent findings in the fields of cellular signaling and cancer stem cells. Lastly, weunderscore the role of SOX2 in the clinic and highlight new findings, which may provide...