The SOX2OT gene is comprised of 10 exons and more than two transcription start sites. Dysregulation of SOX2OT is observed in various tumors, including lung cancer, gastric cancer, esophageal cancer, breast cancer, hepatocellular carcinoma, ovarian cancer, pancreatic ductal adenocarcinoma, laryngeal ...
Conclusion The SOX2-OT/SOX2 axis positively regulates migration of lung squamous H520 cells via Gli1-mediated EMT. Keywords: SOX2-OT; lung squamous cell carcinoma; Gli1; SOX2; epithelial-mesenchymal transition INTRODUCTION According to the GLOBOCAN estimates, lung cancer is the second most commonly ...
SOX2OT 品系描述 These mice carry loxP sites flanking target exons of Sox2ot gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Sox2ot gene. *使用本品系发表的文献需注明: Sox2ot-Flox mice (Cat. NO. TBD) we...
比较两组研究对象的血清lncRNA SOX2-OT水平,心肌重构和心功能相关指标.Pearson相关性分析lncRNA SOX2-OT与心肌重构及心功能相关指标的关系,受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)分析lncRNA SOX2-OT预测CHF患者预后的价值.结果CH...
长链非编码RNA SOX2OT在肝细胞癌组织中的表达及与预后的相关性 廖豪杰李俊熊海林袁霞袁乐中 广东省惠州市中心人民医院(广东惠州，516000)摘要目的:探讨长链非编码RNA(lncRNA)S0X20T在肝细胞癌(HCC)组织中的表达情况，分析其与患者预后的相关性。方法：2017年1月至2019年6月收治的HCC患者120例，采用实时荧光定量...
三唑磷对斑马鱼 H19 和 Sox2OT 基因表达调控的影响 作者: 乔嘉凯,杜羽亭,贾龙略,张丹燕,黄涵年,郭江峰 DOI: 10.16801/j.issn.1008-7303.2019.0047 收稿日期: 2018-12-23 网络首发日期: 2019-05-29 引用格式: 乔嘉凯,杜羽亭,贾龙略,张丹燕,黄涵年,郭江峰.三唑磷对斑马鱼 H19和 Sox2OT 基因表达调控的影响...
Long noncoding RNAs (lncRNAs) show emerging roles in colorectal cancer (CRC) development and are considered to be involved in the potential mechanism of tumor malignancy. While Sox2 overlapping transcript (SOX2OT) has been implicated in the progression o
SOX2 overlapping transcript (SOX2-OT) is an evolutionarily conserved long non-coding RNA (lncRNA) whose intronic region contains the transcript of pluripotency gene SRY-box transcription factor 2 (SOX2). It has been suggested that SOX2-OT can regulate its overlapping gene, SOX2. Studies demonstrate...
Here, we found that SOX2-OT is an upstream trigger of EGFR in HBE cells during long-term PM2.5 exposure. Importantly, SOX2-OT knockdown effectively reduced the colony formation and migration capacities of HBE cells, compared to the wild type control. Collectively, SOX2-OT/microRNA-345-5p/...
SOX2OT与 miR-122-5p表达的相 关性,并分析二者在不同临床 /病 理参数中的差异,Kaplan-Meier生 存曲线分析不同 lncRNA- SOX2OT,miR-122-5p表达患者预后情况.结果 HCC组织中 lncRNA-SOX2OT表达高于癌旁组织,miR-122-5p表达低于 癌旁组织(t=21.258,20.475,P均 <0.001).HCC组织中 lncRNA-SOX2OT与 miR-...