The SOX2OT gene is comprised of 10 exons and more than two transcription start sites. Dysregulation of SOX2OT is observed in various tumors, including lung cancer, gastric cancer, esophageal cancer, breast cancer, hepatocellular carcinoma, ovarian cancer, pancreatic ductal adenocarcinoma, laryngeal ...
Conclusion The SOX2-OT/SOX2 axis positively regulates migration of lung squamous H520 cells via Gli1-mediated EMT. Keywords: SOX2-OT; lung squamous cell carcinoma; Gli1; SOX2; epithelial-mesenchymal transition INTRODUCTION According to the GLOBOCAN estimates, lung cancer is the second most commonly ...
与OV-NC 组相比，OV-SOX2OT 组细胞迁移能力、SIRT1、Beclin1（P <0.001）和p62（P <0.05）蛋白表达、LC3Ⅱ/LC3Ⅰ比值（P <0.001）、SIRT1和LncRNA SOX2OT mRNA （P <0.05）水平均明显增加。沉默SIRT1表达导致LncRNA SOX2OT 过表达的HCCC-9810细胞对5-FU 的耐药性显著降低。与OV-SOX2OT+si-NC 组...
Sox2ot-Flox 品系名:C57BL/6Smoc-Sox2otem1(flox)Smoc 品系状态:在研 | 目录号:待定 Sox2Ot-KO 品系名:C57BL/6Smoc-Sox2Otem1Smoc 品系状态:在研 | 目录号:待定 你也可能感兴趣 Tamoxifen诱导Cre-ERT2小鼠 使用指南 Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxif...
比较两组研究对象的血清lncRNA SOX2-OT水平,心肌重构和心功能相关指标.Pearson相关性分析lncRNA SOX2-OT与心肌重构及心功能相关指标的关系,受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)分析lncRNA SOX2-OT预测CHF患者预后的价值.结果CH...
Results:SOX2-OT was highly expressed in HCC cells and tissues. The prognosis was poor in HCC patients with high SOX2-OT expression. Downregulating SOX2-OT inhibited HCC cell malignant behaviors. SOX2-OT bound to miR-143-3p to promote MSI2 expression. Downregulating miR-143-3p or upregulating ...
Long noncoding RNAs (lncRNAs) show emerging roles in colorectal cancer (CRC) development and are considered to be involved in the potential mechanism of tumor malignancy. While Sox2 overlapping transcript (SOX2OT) has been implicated in the progression o
There are comments on PubPeer for publication: Long noncoding RNA Sox2 overlapping transcript (SOX2OT) promotes non-small-cell lung cancer migration and invasion via sponging microRNA 132 (miR-132) (2018)
摘要: 目的:验证SOX2OT/miRNA(miR)-34a/SOX2信号轴对人大肠癌LOVO细胞侵袭转移的影响以及丹参酚酸B(SalB)通过该信号轴浓度依赖性抑制LOVO细胞侵袭转移。方法:双荧光素酶报告基因检测SOX2OT与miR-34a、miR-34a与SOX2的靶向结合;瞬时转染SOX2OT质粒和miR-34a mimic至LOVO细胞,RT-qPCR验证转染效率;RT-qPCR、Western ...
Here, we found that SOX2-OT is an upstream trigger of EGFR in HBE cells during long-term PM2.5 exposure. Importantly, SOX2-OT knockdown effectively reduced the colony formation and migration capacities of HBE cells, compared to the wild type control. Collectively, SOX2-OT/microRNA-345-5p/...