SOX2OT is a long non-coding RNA that is highly expressed in embryonic stem cells. The SOX2OT gene is comprised of 10 exons and more than two transcription start sites. Dysregulation of SOX2OT is observed in various tumors, including lung cancer, gastric cancer, esophageal cancer, breast ...
LncRNA_SOX2OT靶向SIRT1 LncRNA SOX2OT enhances 5-fluorouracil resistance of cholangiocarcinoma cells by promoting autophagy via up-regulating SIRT1expression XIN Chen 1,WANG Xiaoying 2,LI Xiang 1,CHEN Yu 1,WANG Xue 1,NING Jiaxi 1,YANG Shi 1,WANG Zhongqiong 1 1Department of Gastroenterology,2...
Conclusion The SOX2-OT/SOX2 axis positively regulates migration of lung squamous H520 cells via Gli1-mediated EMT. Keywords: SOX2-OT; lung squamous cell carcinoma; Gli1; SOX2; epithelial-mesenchymal transition INTRODUCTION According to the GLOBOCAN estimates, lung cancer is the second most commonly ...
品系名:C57BL/6Smoc-Sox2otem1(flox)Smoc 品系状态:在研 | 目录号:待定 Sox2Ot-KO 品系名:C57BL/6Smoc-Sox2Otem1Smoc 品系状态:在研 | 目录号:待定 你也可能感兴趣 Tamoxifen诱导Cre-ERT2小鼠 使用指南 Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物...
Long noncoding RNAs (lncRNAs) show emerging roles in colorectal cancer (CRC) development and are considered to be involved in the potential mechanism of tumor malignancy. While Sox2 overlapping transcript (SOX2OT) has been implicated in the progression o
The interactions among SOX2OT, miR-9, and SIRT1 were investigated using luciferase activity assay. Results SOX2OT overexpression significantly alleviated the HG-induced HPCs injury and induced autophagy, which was abrogated by the autophagy inhibitor 3-MA and SIRT1 knockdown. Mechanistically, SOX2OT ...
Fig 2A. "Cell migration was examined by wound healing assay in A549 and H1299 cells transfected with nontargeting sequences (sh-NC) or short-hairpin RNA against SOX2OT (sh-SOX2OT)." I have concerns.Reply permalink report #2 Hoya camphorifolia comment accepted May 2021 Fig 2C. "E-...
Results:SOX2-OT was highly expressed in HCC cells and tissues. The prognosis was poor in HCC patients with high SOX2-OT expression. Downregulating SOX2-OT inhibited HCC cell malignant behaviors. SOX2-OT bound to miR-143-3p to promote MSI2 expression. Downregulating miR-143-3p or upregulating ...
ALKBH5介导长链非编码RNA SOX2OT促进SOX2表达调控胶质瘤替莫唑胺耐药的机制研究 研究背景胶质母细胞瘤(glioblastoma GBM)是颅内恶性肿瘤之首,标准治疗方案为手术切除加术后同步放化疗,患者预后差,中位生存期仅14个月,且极易复发.替莫唑胺(Temozolom... 刘伯杨 - 《南方医科大学》 被引量: 0发表: 2019年...
摘要: 目的:验证SOX2OT/miRNA(miR)-34a/SOX2信号轴对人大肠癌LOVO细胞侵袭转移的影响以及丹参酚酸B(SalB)通过该信号轴浓度依赖性抑制LOVO细胞侵袭转移。方法:双荧光素酶报告基因检测SOX2OT与miR-34a、miR-34a与SOX2的靶向结合;瞬时转染SOX2OT质粒和miR-34a mimic至LOVO细胞,RT-qPCR验证转染效率;RT-qPCR、Western ...