Mechanism of action Sotalol inhibits beta-1 adrenoceptors in the myocardium as well as rapid potassium channels to slow repolarization, lengthen the QT interval, and slow and shorten conduction of action potentials through the atria.2,3,4,5 The action of sotalol on beta adrenergic receptors length...
Mechanism of Action Beta adrenergic receptor antagonists; Potassium channel antagonists Orphan Drug Status No Highest Development Phases Marketed Atrial fibrillation; Atrial flutter Most Recent Events 04 Apr 2007 Berlex Inc has been acquired by Bayer HealthCare 09 Oct 2002 A study has been ad...
This hypothesis is supported by the results of recent experimental studies involving elucidation of the mechanism of antiarrhythmic-defibrillating effects of sotalol. Enhancement of intercellular communication and myocardial synchronization are thought to play critical role in the mechanism of action of this...
sotalol hydrochloride is an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias. Mechanism of action Sotalol acts as an antiarrhythmic by β- receptor blockade as well as by prolonging the action potential duration in atrium and ventricle and the refractory period...
Sotalol-d6 Hydrochloride is a deuterium labeled compound categorized with class III antiarrhythmic activity with a mechanism of action that prolongs the action potential and refraction of cardiac tissue through non-selective yet potent β-adronergic blocking activity. The compound does not retain any me...
Antiarrhythmic action begins at 1 h after ingestion, reaches a maximum 2.5-4 hours and lasts 24 hours. The on / in a dose of 40 mg of effect occurs within 5 minutes and lasts for 90-120 minutes. Effective for arrhythmias with the mechanism of re-entry, especially in atrial fibrillation....
This article aims to review the mechanism of action of sotalol, the 尾-blocking effects on heart failure, and provide an overview of clinical trials on sotalol use and its effects in patients with heart failure. Small- and large-scale clinical trials have been controversial and inconclusive ...
Sotalol (2:1 ratio (d:l)) resulted in complete protection against ventricular tachycardia at a dosage of 2.5 mg/kg. MECHANISM OF ACTION : beta -adrenergic antagonist.SANKARANARAYANAN, ALANGUDI
Evaluates the effectiveness of sotalol compared with class I antiarrhythmic drugs in the treatment for ventricular tachyarrhythmias. Lower incidence of arrhythmia recurrence in patients receiving sotalol; Mechanism of action of sotalol; Cumulative all-cause mortality after the use of the drugs; Efficacy ...
Sotalol (2:1 ratio (d:l)) resulted in complete protection against ventricular tachycardia at a dosage of 2.5 mg/kg. MECHANISM OF ACTION : beta -adrenergic antagonist.doi:WO2000045807 A1ALANGUDI SANKARANARAYANANWO