Sotalol is a competitive inhibitor of the rapid potassium channel.2 This inhibition lengthens the duration of action potentials and the refractory period in the atria and ventricles.3,4 The inhibition of rapid potassium channels is increases as heart rate decreases, which is why adverse effects like...
A racemic mixture of d- and l-sotalol, with beta-blocking (class II) and cardiac action potential duration prolongation (class-III antiarrhythmic properties). Adverse effects Fatigue, bradycardia, proarrhythmia, dyspnea, diarrhoea, nausea, vomiting, QT-interval prolongation, nonspecific increase in liv...
A process is provided for preventing or ameliorating arrhythmia by administering to mammals, including man, an effective dose of d-sotalol to lengthen the action potential duration of cardiac cell without blockade of beta-adrenergic receptor sites.SIMON, ARTHUR, POMONA, N.Y., US...
摘要: A process is provided for preventing or ameliorating arrhythmia by administering to mammals, including man, an effective dose of d-sotalol to lengthen the action potential duration of cardiac cell without blockade of beta-adrenergic receptor sites....
As it has become increasingly difficult to advocate the use of class I antiarrhythmic agents, many centers are now preferentially using compounds that predominantly prolong action potential duration and refractoriness (i.e., class III agents like amiodarone or d,l-sotalol). However, data on the ...
Adverse reactions that are clearly related to sotalol are those which are typical of its Class II (beta-blocking) and Class III (cardiac action potential duration prolongation) effects and are dose related. Ventricular Arrhythmias Serious Adverse Reactions Sotalol hydrochloride/sotalol hydrochloride AF...
These effects remained constant for five days, the duration of the chronic study. The drug, in doses two to three times larger than that required to inhibit the chronotropic action of isoproterenol, was well tolerated and produced no untoward or toxic effects in either the acute or chronic ...
of class III antiarrhythmicdrugs, in that it prolongs the duration of the action potentialand, thus, increases the effective refractory period of myocardialtissue. It is distinguished from the other class III drugs(amiodarone and bretylium) because of its -adrenergicreceptor–blocking action. ...
This study was performed to determine whether Sotalol acts as a beta adrenergic receptor blocking agent when given intravenously to man, the dose at which it blocks the beta adrenergic stimulating effect of an intravenous infusion of isoproterenol, the duration and constancy of its action and ...
Kind Code: A1 Abstract: A process is provided for preventing or ameliorating arrhythmia by administering to mammals, including man, an effective dose of d-sotalol to lengthen the action potential duration of cardiac cell without blockade of beta-adrenergic receptor sites. ...