A beta-blocker drug, C12H20N2O3S, used in its hydrochloride form to treat certain cardiac arrhythmias. [Alteration ofsorta(because sotalol is only "sort of" a beta-blocker, since it also has antiarrhythmic effects related to the cellular transport of potassium ions) +(proprano)lol.] ...
Initial dose is 80 mg twice daily, with gradual titration to 240 to 360 mg/day as needed. The daily dose must be reduced in renal failure. On the basis of favorable clinical trials and practice experience, sotalol has shown a steadily growing impact on the treatment of arrhythmias during ...
In rabbits, a high dose of Sotalol HCl (160 mg/kg/day) at 16 times the MRHD as mg/kg (6 times the MRHD as mg/m2) produced a slight increase in fetal death likely due to maternal toxicity. Eight times the maximum dose (80 mg/kg/day or 3 times the MRHD as mg/m2) did not...
Likewise, patients’ regular 80-, 160-, and 240-mg tablets, initial dosing with 80 mg twice daily, daily dosages between 160 and 320 mg or 480 mg, may reach dosages as high as 640 mg/d [84,85]. Contrarily, the use of the consistently higher range may approach the worst ...
According to our hospital pharmacy, the cost of amiodarone, 200mg/day, is approximately US $8.10. Sotalol, 160 mg (80 mg twice/d), is approximately $9.70 a day; with titration of sotalol up to 3 times to 480 mg/day, the cost would be over $28/day, substantially more than the ...
There was no structural cardiac defect Before the initiation of sotalol therapy, maternal electrolytes and ECGs were performed to exclude preexisting arrhythmias The sotalol dose started with 80 mg twice a day and increased to 160 mg three times per day, the fetus successfully converted ...
Methods. Two hundred seven consecutive coronary artery bypass patients (mean age 62 卤 11 years) were randomized to receive sotalol alone (80 mg twice daily for 5 days starting from the morning of the first postoperative day) (group S), magnesium alone (1.5 g daily for 6 days starting in...
BACKGROUND: The current recommended starting dose of sotalol is 80 mg orally twice per day, followed by a judicious increase in dosage every 3 days under continuous telemetry monitoring. We hypothesized that sotalol administered at a higher starting dose (120 or 160 mg twice daily) would allow ...
Side Effects, Sotalol HClConcise Info
After the initial loading phase, the drug dose was tapered to maintenance levels over 7 to 12 days; thereafter, therapy was generally maintained at a dosage of 200 mg/day. The sotalol dosage was 80 to 360 mg twice daily, as tolerated. Follow-up clinical evaluations were conducted at 1, ...