It might also carry information that is important for trafficking of the GPI-anchored proteins.After exiting the endoplasmic reticulum (ER), GPI-anchored proteins are segregated into vesicles that are distinct from those carrying other secretory and plasma membrane proteins. Proteins that were ...
First, GPI-anchored proteins are laterally segregated from other membrane proteins; second, they are concentrated into budding vesicles. Abstract The study of glycosylphosphatidylinositol-anchored-protein sorting has led to some surprising new findings and concepts. Evidence is accumulating that, during ...
► GPI-anchor functions as a sorting signal for transport of GPI-anchored proteins. ► During delivery to the plasma membranes, the GPI moiety is remod... M Fujita,T Kinoshita - BBA - Molecular and Cell Biology of Lipids 被引量: 243发表: 2012年 N-Glycans, not the GPI anchor, media...
Sorting GPI-anchored proteins. Nat Rev Mol Cell Biol 2004; 5:110-120. 62 Brown DA, Crise B, Rose JK. Mechanism of membrane anchoring affects polarized expression of two proteins in MDCK cells. Science 1989; 245:1499-1501. 63 Lisanti MP, Sargiacomo M, Graeve L, Saltiel AR, Rodri- gu...
In this work, we show that the Rab GTPase Ypt1p and the tethering factors Uso1 and Sec34/35p, but not the TRAPP complex, are necessary for sorting of GPI-anchored proteins upon ER exit. Using an in vitro assay that reconstitutes the ER-derived vesicle budding, we showed that sorting ...
To understand the mechanism involved in the apical sorting of glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) we fused to the C-terminus of GFP the GPI-anchor-attachment signal of the folate receptor (FR) or of the prion protein (PrP), two native GPI-anchored proteins that are...
We studied the role of the association between glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipid (GSL) clusters in apical targeting using gD1-DAF, a GPI-anchored protein that is differentially sorted by three epithelial cell lines. Differently from MDCK cells, where both gD...
Glycosyl-phosphatidylinositol (GPI)-anchored proteins (GPI-APs) are present at the surface of living cells in cholesterol dependent nanoscale clusters. The... R Chadda,MT Howes,SJ Plowman,... - 《Traffic》 被引量: 188发表: 2010年 The epithelial-specific adaptor AP1B mediates post-endocytic re...
1992. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68: 533–544. Brown MC, Besio-Moreno M, Bongarzone ER, Cohen PD, Soto EF, et al. 1993. Vesicular... SN Fewou,N Jackman,GV Meer,... - Springer US 被引...
Iwaki T. et al.Loss of a GPI-anchored membrane protein Aah3p causes a defect in vacuolarprotein sorting in Schizosaccharomyces pombe. Bioscience Biotechnology and Biochemistry . 2007Loss of a GPI-anchored membrane protein Aah3p causes a defect in vacuolarprotein sorting in Schizosaccharomyces pombe. ...